Inhibition of Phytosterol Biosynthesis by Azasterols
| Autor: | Laetitia B. B. Martin, Franz Bracher, Philippe Geoffroy, Pierre Mercier, Hubert Schaller, Sylvain Darnet |
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| Přispěvatelé: | Federal University of Para - Universidade Federal do Para [Belem - Brésil], Institut de biologie moléculaire des plantes (IBMP), Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA), Ludwig-Maximilians University [Munich] (LMU), Institut de Chimie de Strasbourg, Centre National de la Recherche Scientifique (CNRS)-Université Louis Pasteur - Strasbourg I-Institut de Chimie du CNRS (INC) |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0106 biological sciences
Azasteroids Campesterol [SDV]Life Sciences [q-bio] Arabidopsis Pharmaceutical Science 01 natural sciences Article Analytical Chemistry lcsh:QD241-441 03 medical and health sciences chemistry.chemical_compound Biosynthesis lcsh:Organic chemistry SBI Drug Discovery polycyclic compounds fungicide Arabidopsis thaliana [CHIM]Chemical Sciences Enzyme Inhibitors Physical and Theoretical Chemistry 030304 developmental biology chemistry.chemical_classification 0303 health sciences biology Arabidopsis Proteins Phytosterol Organic Chemistry Phytosterols food and beverages cholesterol Methyltransferases biology.organism_classification Sterol steroidogenesis inhibitor Enzyme chemistry Biochemistry sitosterol Chemistry (miscellaneous) Molecular Medicine lipids (amino acids peptides and proteins) selective herbicide Function (biology) 010606 plant biology & botany |
| Zdroj: | Molecules Molecules, MDPI, 2020, 25 (5), ⟨10.3390/molecules25051111⟩ Molecules, Vol 25, Iss 5, p 1111 (2020) Volume 25 Issue 5 |
| ISSN: | 1420-3049 |
| DOI: | 10.3390/molecules25051111⟩ |
| Popis: | International audience; Inhibitors of enzymes in essential cellular pathways are potent probes to decipher intricate physiological functions of biomolecules. The analysis of Arabidopsis thaliana sterol profiles upon treatment with a series of azasterols reveals a specific in vivo inhibition of SMT2, a plant sterol-C-methyltransferase acting as a branch point between the campesterol and sitosterol biosynthetic segments in the pathway. Side chain azasteroids that modify sitosterol homeostasis help to refine its particular function in plant development. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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