Localization of Gastrointestinal Deposition of Mercuric Chloride Studiedin Vivo

Autor: Jens Ahm Sørensen, H L Andersen, Jesper Bo Nielsen, Ole Andersen
Rok vydání: 1992
Předmět:
Zdroj: Nielsen, J B, Andersen, H L, Sørensen, J A & Andersen, O 1992, ' Localization of Gastrointestinal Deposition of Mercuric Chloride Studied in Vivo ', Pharmacology & Toxicology, vol. 70, no. 4, pp. 262-267 . https://doi.org/10.1111/j.1600-0773.1992.tb00468.x
ISSN: 1600-0773
0901-9928
DOI: 10.1111/j.1600-0773.1992.tb00468.x
Popis: During the last 5 years, the site of gastrointestinal absorption of inorganic mercury has been attempted identified mainly by experiments using perfused intestinal segments in vitro or in situ. The present investigation will discuss the localization of the absorption site for mercuric chloride based on a completely undisturbed in vivo experimental model in mice. As the mice were allowed to eat their normal diet during the experimental period, the present results would independently add to existing knowledge on intestinal absorption sites for inorganic mercury. The mice were given 203Hg labelled mercuric chloride orally, either through stomach tube or in the drinking water, and were killed after various time intervals. Mercury was localized and quantified in various segments of the gastrointestinal tract by gamma‐counting. Time course analysis of the segmental deposition of mercury demonstrated that the deposition mainly takes place in the proximal jejunum and suggested that a larger part of the jejunum than previously reported is involved in absorption of mercury. Using this in vivo model, tetraethylthiuram disulfide was demonstrated to increase the intestinal deposition and absorption without changing the site of deposition. 1992 Nordic Pharmacological Society
Databáze: OpenAIRE
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