Extended superfamily of short alcohol-polyol-sugar dehydrogenases: structural similarities between glucose and ribitol dehydrogenases
| Autor: | Hedvig von Bahr-Lindström, Wolfgang Ulmer, Klaus-Dieter Jany, Hans Jörnvall, Marion Fröschle |
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| Rok vydání: | 1984 |
| Předmět: |
L-Iditol 2-Dehydrogenase
Superfamily Glucose Dehydrogenases Biophysics Alcohol oxidoreductase Saccharomyces cerevisiae Ribitol Carbohydrate Dehydrogenases Biochemistry chemistry.chemical_compound Structural Biology Glucose dehydrogenase Genetics Animals Amino Acid Sequence Horses Non-zinc alcohol dehydrogenase Molecular Biology Alignment Alcohol dehydrogenase Sheep biology Short dehydrogenase Alcohol Dehydrogenase Glucose 1-Dehydrogenase Cell Biology Homology Alcohol Oxidoreductases Klebsiella pneumoniae Drosophila melanogaster chemistry Bacillus megaterium biology.protein Sorbitol Sugar Alcohol Dehydrogenases |
| Zdroj: | FEBS Letters. 165:190-196 |
| ISSN: | 0014-5793 |
| DOI: | 10.1016/0014-5793(84)80167-2 |
| Popis: | The recently determined primary structure of glucose dehydrogenase from Bacillus megaterium was scanned by computerized comparisons for similarities with known polyol and alcohol dehydrogenases. The results revealed a highly significant similarity between this glucose dehydrogenase and ribitol dehydrogenase from Klebsiella aerogenes. Sixty-one positions of the 262 in glucose dehydrogenase are identical between these two proteins (23% identity), fitting into a homology alignment for the complete polypeptide chains. The extent of similarity is equivalent to that between other highly divergent but clearly related dehydrogenases (two zinc-containing alcohol dehydrogenases, 25% sorbitol and zinc-containing alcohol dehydrogenases, 25%; ribitol and non-zinc-containing alcohol dehydrogenases, 20%), and suggests an ancestral relationship between glucose and ribitol dehydrogenases from different bactera. The similarities fit into a previously suggested evolutionary scheme comprising short and long alcohol and polyol dehydrogenases, and greatly extend the former group to one composed of non-zinc-containing alcohol-polyol-glucose dehydrogenases. |
| Databáze: | OpenAIRE |
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