A destabilised metabolic niche provokes loss of a subpopulation of aged muscle stem cells

Autor: Brendan Evano, Shahragim Tajbakhsh
Přispěvatelé: Cellules Souches et Développement / Stem Cells and Development, Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS), Institut Pasteur [Paris]-Centre National de la Recherche Scientifique (CNRS)
Jazyk: angličtina
Rok vydání: 2019
Předmět:
MESH: Signal Transduction
Satellite Cells
Skeletal Muscle
[SDV]Life Sciences [q-bio]
Niche
Organ function
Mouse Muscle
[SDV.BC.BC]Life Sciences [q-bio]/Cellular Biology/Subcellular Processes [q-bio.SC]
Biology
Granulocyte
General Biochemistry
Genetics and Molecular Biology
Genetic Heterogeneity
Mice
03 medical and health sciences
0302 clinical medicine
Granulocyte Colony-Stimulating Factor
medicine
Animals
News & Views
MESH: Animals
Molecular Biology
MESH: Mice
Cellular Senescence
030304 developmental biology
0303 health sciences
General Immunology and Microbiology
General Neuroscience
MESH: Genetic Heterogeneity
MESH: Satellite Cells
Skeletal Muscle
MESH: Cellular Senescence
Cell biology
medicine.anatomical_structure
Ageing
MESH: Granulocyte Colony-Stimulating Factor
Stem cell
030217 neurology & neurosurgery
Function (biology)
Signal Transduction
Zdroj: EMBO Journal
EMBO Journal, 2019, 38 (24), pp.e103924. ⟨10.15252/embj.2019103924⟩
EMBO Journal, EMBO Press, 2019, 38 (24), pp.e103924. ⟨10.15252/embj.2019103924⟩
EMBO J
ISSN: 0261-4189
1460-2075
DOI: 10.15252/embj.2019103924⟩
Popis: International audience; Ageing is a multi-factorial condition that results in a gradual decline in tissue and organ function. Systemic, local and intrinsic factors play major roles in this process that also results in a decline in stem cell number and function. In this issue of The EMBO Journal, Li et al (2019) show that a subpopulation of mouse muscle stem cells is depleted in aged mice through loss of niche-derived granulocyte colony-stimulating factor (G-CSF).
Databáze: OpenAIRE
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