Effects of 12-WeekBacopa monnieriConsumption on Attention, Cognitive Processing, Working Memory, and Functions of Both Cholinergic and Monoaminergic Systems in Healthy Elderly Volunteers

Autor: Supaporn Muchimapura, Jintanaporn Wattanathorn, Poonsri Rangseekajee, Tatimah Peth-Nui, Kornkanok Ingkaninan, Nawanant Piyavhatkul, Terdthai Tong-Un, Sakchai Vittaya-areekul
Rok vydání: 2012
Předmět:
Zdroj: Evidence-Based Complementary and Alternative Medicine, Vol 2012 (2012)
Evidence-based Complementary and Alternative Medicine : eCAM
ISSN: 1741-4288
1741-427X
DOI: 10.1155/2012/606424
Popis: At present, the scientific evidence concerning the effect ofBacopa monnierion brain activity together with working memory is less available. Therefore, we aimed to determine the effect ofB. monnierion attention, cognitive processing, working memory, and cholinergic and monoaminergic functions in healthy elderly. A randomized double-blind placebo-controlled design was utilized. Sixty healthy elderly subjects (mean age 62.62 years; SD 6.46), consisting of 23 males and 37 females, received either a standardized extract ofB. monnieri(300 and 600 mg) or placebo once daily for 12 weeks. The cholinergic and monoaminergic systems functions were determined using AChE and MAO activities. Working memory was assessed using percent accuracy and reaction time of various memory tests as indices, whereas attention and cognitive processing were assessed using latencies and amplitude of N100 and P300 components of event-related potential. All assessments were performed before treatment, every four weeks throughout study period, and at four weeks after the cessation of intervention.B. monnieri-treated group showed improved working memory together with a decrease in both N100 and P300 latencies. The suppression of plasma AChE activity was also observed. These results suggest thatB. monnierican improve attention, cognitive processing, and working memory partly via the suppression of AChE activity.
Databáze: OpenAIRE
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