Characterization of coumarins from Ipomoea mauritiana Jacq by LC-APCI-MS/MS analysis and evaluation of its anti-amnesic activity
| Autor: | Lijini K. R, Sunil A.R, Indira Balachandran, Sulaiman C T, Deepak M |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
LC-APCI-MS
Pharmaceutical Science Medicine (miscellaneous) Atmospheric-pressure chemical ionization Coumarin 01 natural sciences Anti-amnesic activity 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Step through latency heterocyclic compounds lcsh:Science Mauritiana lcsh:R5-920 Ipomoea mauritiana biology Traditional medicine 010405 organic chemistry Chemistry Ms analysis biology.organism_classification Agricultural and Biological Sciences (miscellaneous) 0104 chemical sciences Lc apci ms ms Scopolamine induced amnesia lcsh:Q lcsh:Medicine (General) 030217 neurology & neurosurgery |
| Zdroj: | Beni-Suef University Journal of Basic and Applied Sciences, Vol 8, Iss 1, Pp 1-8 (2019) |
| ISSN: | 2314-8543 |
| Popis: | Background Ipomoea mauritiana is one of the source plants of Vidari, an Ayurvedic drug used as Medhyarasayana (rejuvenating drug). In this current study, coumarins were separated from tuberous root of I. mauritiana and characterization of the coumarin fraction was done by LC-MS/MS analysis by atmospheric pressure chemical ionization method. Anti-amnesic activity was evaluated against scopolamine induced amnesia in Wistar rats. Results Mass spectroscopic characterization of coumarin fraction directed to the tentative identification of coumarins such as 7-hydroxy-6-methoxy coumarin, 7-hydroxycoumarin, 5-methoxy-6,7-furanocoumarin, 5,7-dimethoxycoumarin, and 6-hydroxy-7-methoxy-4-phenylcoumarin. Aqueous extract of I. mauritiana at a dose of 100 and 200 mg/kg showed significant anti-amnesic activity against scopolamine-induced changes in step through latency and working memory errors. Conclusion The findings of the study showed that I. mauritiana is a rich source of coumarins and possessed significant anti-amnesic activity. The study concluded the scientific basis of using I. mauritiana as rejuvenating drug in Ayurveda. Graphical abstract |
| Databáze: | OpenAIRE |
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