Inter- and intramyotomal gap junctions in the axolotl embryo
| Autor: | Pat G. Model, George D. Pappas, Joe S. Keeter |
|---|---|
| Rok vydání: | 1975 |
| Předmět: |
Embryo
Nonmammalian Neuromuscular Junction Connective tissue Gestational Age Biology Ambystoma Myofibrils Cell Movement Myotome Axolotl medicine Animals Myocyte Ambystoma mexicanum Molecular Biology Myogenesis Muscles Gap junction Cell Differentiation Cell Biology Anatomy biology.organism_classification Cell biology medicine.anatomical_structure Myofibril Muscle Contraction Developmental Biology |
| Zdroj: | Developmental Biology. 45:21-33 |
| ISSN: | 0012-1606 |
| DOI: | 10.1016/0012-1606(75)90237-7 |
| Popis: | In early tailbud embryos of the axolotl ( Ambystoma mexicanum ), cells of the anterior myotomes begin to elongate and align along the longitudinal axis of the animal. Soon thereafter, gap junctions appear between the differentiating myotubes. These junctions occur between adjacent cells within a myotome (intramyotomal) and between the cells of adjacent myotomes which are separated from one another by narrow connective tissue septa (intermyotomal). The latter are found at the ends of the elongating cells where muscle-tendon insertion will occur and nerve-muscle synapses will form. The gap junctions are transient: They appear with the onset of myofibrillar formation at the time that nerve fibers enter the intermyotomal septa. The junctions last until the cells have differentiated into mature striated muscle cells and neuromuscular synapses are fully developed. These gap junctions may provide a means for the direct intercellular spread of electrical excitation between the differentiating muscle cells and so account for the observed myogenic contraction of myotomes. We also suggest that these junctions may form a means for cellular communication and interaction during the development of the axial musculature. |
| Databáze: | OpenAIRE |
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