Effects of stimulation frequency and intensity in sacral neuromodulation on anorectal inputs to the somatosensory cortex in an experimental model
| Autor: | Charles H. Knowles, P. R. O'Connell, Liam A Devane, E V Carrington, Stephen Scott, James F. X. Jones, Judith Evers |
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| Rok vydání: | 2014 |
| Předmět: |
Frequency response
medicine.medical_specialty Partial Pressure Lumbosacral Plexus Anal Canal Blood Pressure Electric Stimulation Therapy Stimulation Somatosensory system Animal data Evoked Potentials Somatosensory medicine Animals Fecal incontinence Rats Wistar business.industry Somatosensory Cortex Carbon Dioxide Anal canal Intensity (physics) Surgery medicine.anatomical_structure Hematocrit Sacral nerve stimulation Female medicine.symptom business Fecal Incontinence Biomedical engineering |
| Zdroj: | British Journal of Surgery. 101:1317-1328 |
| ISSN: | 1365-2168 0007-1323 |
| DOI: | 10.1002/bjs.9587 |
| Popis: | Introduction Although sacral neuromodulation (SNM) is an established treatment for faecal incontinence, stimulation parameters have been derived empirically and only one frequency (14 Hz) is employed clinically. The aim of this study was to test a range of stimulation frequencies to establish an optimal frequency of SNM for maximum augmentation of anal canal cortical evoked potentials (EPs) in an animal model. Methods In female Wistar rats, anal canal EPs were recorded over the primary somatosensory cortex using a flexible multielectrode array, and the effect of SNM was studied. SNM was applied at 0·1–100 Hz and a frequency response curve plotted. The data were fitted to a quadratic equation. Results The magnitude of potentiation of anal canal EPs caused by SNM depended significantly on stimulation frequency (P |
| Databáze: | OpenAIRE |
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