The Effect of Evodia Rutaecarpa Extract on Cytokine Secretion by Human Mononuclear Cells in vitro
| Autor: | Jan-Growth Chang, Chih-Peng Chang, Jan-Yi Chang, Fang-Yu Wang, Jerming Tseng |
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| Rok vydání: | 1995 |
| Předmět: |
Time Factors
medicine.medical_treatment In Vitro Techniques Pharmacology Peripheral blood mononuclear cell Monocytes Magnoliopsida medicine Humans Secretion Medicine Chinese Traditional Interleukin 6 Cells Cultured Dose-Response Relationship Drug biology Traditional medicine business.industry Interleukin General Medicine Colony-stimulating factor In vitro Cytokine Complementary and alternative medicine biology.protein Cytokines Cytokine secretion business Interleukin-1 Phytotherapy |
| Zdroj: | The American Journal of Chinese Medicine. 23:173-180 |
| ISSN: | 1793-6853 0192-415X |
| DOI: | 10.1142/s0192415x95000237 |
| Popis: | The effect of Evodia rutaecarpa extract on cytokine secretion by human mononuclear cells in vitro was investigated. Evodia rutaecarpa extract of various concentrations in mononuclear cell culture medium showed biphasic effects on the secretion of interleukin 1 beta (IL-1 beta), interleukin 6 (IL-6), tumor necrosis factor alpha (TNF-alpha), and granulocyte-macrophage colony stimulating factor (GM-CSF) by the mononuclear cells. Generally speaking, a low to medium level of Evodia rutaecarpa extract, in concentrations ranging from 10% to 30%, showed significant stimulating effects on the secretion of IL-1 beta, IL-6, TNF-alpha and GM-CSF. On the other hand, high level of Evodia rutaecarpa extract, with concentration more than 40%, lost its stimulating effects. Moreover, reaction time affected the stimulating effects of Evodia rutaecarpa extract on cytokine secretion by mononuclear cells. Mononuclear cell culture medium containing Evodia rutaecarpa extract that was allowed to react for 18 or 24 hours showed significantly better stimulating effects than that reacted for 1 or 3 hours. |
| Databáze: | OpenAIRE |
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