The separate and combined effects of MHC genotype, parasite clone, and host gender on the course of malaria in mice
| Autor: | Mirjam Walker, Tom J. Little, Claus Wedekind |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2006 |
| Předmět: |
Male
Animals Clone Cells Disease Progression Female Genetic Predisposition to Disease Genotype H-2 Antigens/genetics Haplotypes Major Histocompatibility Complex/genetics Malaria/genetics Malaria/parasitology Mice Mice Congenic Plasmodium chabaudi Sex Factors lcsh:QH426-470 Clone (cell biology) Overdominance chemical and pharmacologic phenomena Major histocompatibility complex Loss of heterozygosity Major Histocompatibility Complex Genetics Genetics (clinical) biology Haplotype H-2 Antigens Heterozygote advantage biology.organism_classification Malaria lcsh:Genetics Immunology biology.protein Research Article |
| Zdroj: | Wedekind, C, Walker, M & Little, T 2006, ' The separate and combined effects of MHC genotype, parasite clone, and host gender on the course of malaria in mice ', BMC Genetics, vol. 7, no. 55, pp.-. https://doi.org/10.1186/1471-2156-7-55 BMC Genetics, vol. 7, pp. 55 BMC Genetics BMC Genetics, Vol 7, Iss 1, p 55 (2006) |
| DOI: | 10.1186/1471-2156-7-55 |
| Popis: | Background The link between host MHC (major histocompatibility complex) genotype and malaria is largely based on correlative data with little or no experimental control of potential confounding factors. We used an experimental mouse model to test for main effects of MHC-haplotypes, MHC heterozygosity, and MHC × parasite clone interactions. We experimentally infected MHC-congenic mice (F2 segregants, homo- and heterozygotes, males and females) with one of two clones of Plasmodium chabaudi and recorded disease progression. Results We found that MHC haplotype and parasite clone each have a significant influence on the course of the disease, but there was no significant host genotype by parasite genotype interaction. We found no evidence for overdominance nor any other sort of heterozygote advantage or disadvantage. Conclusion When tested under experimental conditions, variation in the MHC can significantly influence the course of malaria. However, MHC heterozygote advantage through overdominance or dominance of resistance cannot be assumed in the case of single-strain infections. Future studies might focus on the interaction between MHC heterozygosity and multiple-clone infections. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|