Expression and clinical significance of Apollon in esophageal squamous cell carcinoma
| Autor: | Ren‑Wei Guo, Bo‑Lin Chen, Yan‑Wu Zhou, Ai‑Min Leng, Rong Li, Meng‑Ting Shuai, Jun‑Xian Zeng |
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| Rok vydání: | 2015 |
| Předmět: |
0301 basic medicine
Adult Male Cancer Research Pathology medicine.medical_specialty Apollon Esophageal Neoplasms Biology medicine.disease_cause Biochemistry Inhibitor of Apoptosis Proteins 03 medical and health sciences 0302 clinical medicine inhibitors of apoptosis protein Genetics medicine Carcinoma Humans Molecular Biology Lymph node Survival analysis Aged Oncogene apoptosis Cancer Articles Middle Aged medicine.disease Prognosis Molecular medicine Survival Analysis digestive system diseases esophageal squamous cell carcinoma Gene Expression Regulation Neoplastic 030104 developmental biology medicine.anatomical_structure Oncology 030220 oncology & carcinogenesis Cancer research Carcinoma Squamous Cell Molecular Medicine Immunohistochemistry Female Carcinogenesis |
| Zdroj: | Molecular Medicine Reports |
| ISSN: | 1791-3004 |
| Popis: | Apollon, an unusually large member of the inhibitors of apoptosis protein family, may be important for oncogenesis development. The aim of the present study was to assess the association between esophageal squamous cell carcinoma (ESCC) and Apollon expression levels, and to highlight the association between Apollon and the occurrence, development and prognosis of ESCC. Apollon expression was detected by immunohistochemical staining and reverse transcription-quantitative polymerase chain reaction in ESCC tissues, adjacent non‑cancerous tissues and paired normal tissues respectively, in order to analyze the association between Apollon expression and the clinicopathological features of ESCC. Survival analysis was used to assess the prognostic significance of Apollon expression. It was determined that the mRNA and protein expression levels of Apollon were significantly higher in the carcinoma tissues compared with the adjacent non‑cancerous tissues and normal control tissues (P |
| Databáze: | OpenAIRE |
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