Abnormal Regional and Global Connectivity Measures in Subjective Cognitive Decline Depending on Cerebral Amyloid Status

Autor: Frank Jessen, Steffen Wolfsgruber, Cihan Catak, Laura Dobisch, Anja Schneider, Christoph Laske, Ingo Kilimann, Birgit Ertl-Wagner, Klaus Fliessbach, Alfredo Ramirez, Catharina Lange, Josef Priller, Bernd J. Krause, Eike Jakob Spruth, Angelika Maurer, Emrah Düzel, Marcel Daamen, Michael Wagner, Klaus Scheffler, Shumei Li, Nina Roy, Stefan J. Teipel, Henning Boecker, John-Dylan Haynes, Florian Gaertner, Enise I. Incesoy, Alexander Drzezga, Matthias Reimold, Annika Spottke, Axel Rominger, Maike Tscheuschler, Oliver Peters, Markus Essler, Katharina Buerger, Lukas Scheef, Martina Buchmann, Ralph Buchert
Rok vydání: 2020
Předmět:
0301 basic medicine
Male
Precuneus
diagnostic imaging [Cognitive Dysfunction]
Correlation
Cohort Studies
0302 clinical medicine
Parietal Lobe
Stilbenes
Cognitive decline
Aniline Compounds
medicine.diagnostic_test
General Neuroscience
Functional connectivity
Confounding
prodromal symptoms
pathology [Parietal Lobe]
amyloid
General Medicine
Magnetic Resonance Imaging
Psychiatry and Mental health
Clinical Psychology
medicine.anatomical_structure
Cardiology
Female
Alzheimer’s disease
medicine.medical_specialty
metabolism [Amyloid beta-Peptides]
Standardized uptake value
occipital cortex
03 medical and health sciences
precuneus
Internal medicine
mental disorders
medicine
Dementia
Humans
Cognitive Dysfunction
ddc:610
Aged
Amyloid beta-Peptides
business.industry
medicine.disease
functional magnetic resonance imaging
030104 developmental biology
PET
Geriatrics and Gerontology
subjective cognitive decline
Functional magnetic resonance imaging
business
030217 neurology & neurosurgery
Zdroj: Journal of Alzheimer's disease 79(2), 493-509 (2021). doi:10.3233/JAD-200472
Journal of Alzheimer's Disease
DOI: 10.21203/rs.2.23489/v1
Popis: Background: While cerebral beta-amyloid accumulation was found in many studies to alter precuneus-based functional connectivity (FC) in mild cognitive impairment and demented Alzheimer’s disease (AD) patients, its impact is less well understood in subjective cognitive decline (SCD), which in the presence of underlying AD pathologic change corresponds to a progression to stage 2 of the clinical Alzheimer’s continuum in the 2018 National Institute on Aging and Alzheimer’s Association research framework, and represents the earliest clinical manifestation of AD. Methods: From the DELCODE (DZNE – Longitudinal Cognitive Impairment and Dementia Study) cohort, two groups of 24 age- and gender-matched amyloid-positive SCD (SCDAβ+) and amyloid-negative SCD (SCDAβ-) patients were selected according to visual [18F]-Florbetaben PET readings, and studied with resting-state BOLD fMRI. Local (regional homogeneity (ReHo), amplitude of low-frequency fluctuation (ALFF) and fractional ALFF (fALFF)) and global (degree centrality (DC), precuneus seed-based FC maps) measures were calculated and compared between both groups. Furthermore, follow-up correlation analyses probed linear relationships of observed group differences with global as well as precuneal amyloid load measured by Florbetaben standard uptake value ratios (SUVRFBB). Results: For the local measures, ReHo was significantly higher in the bilateral precuneus for the SCDAβ+ group, whereas ALFF and fALFF measures were not altered between groups. For the global measures, relatively higher precuneus-based FC with occipital areas (but no altered DC) was observed in the SCDAβ+ group. Moreover, the FC differences between precuneus and occipital areas were positively correlated with global (SCDAβ+) and local precuneus SUVRFBB (both groups). Conclusions: While confounding influences due to a higher ratio of APOE e4 carriers in the SCDAβ+ group cannot be excluded, results indicate functional alterations in the precuneus hub region that were linearly related to beta-amyloid load, highlighting incipient pathology and possible compensatory mechanisms in stage 2 of the AD continuum.
Databáze: OpenAIRE
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