Pharmacological dose of {alpha}-tocopherol induces cardiotoxicity in Wistar rats determined by echocardiography and histology
| Autor: | Flávio A. Carvalho, Beatriz Bojikian Matsubara, Kyung-Jin Yeum, Ana Lúcia dos Anjos Ferreira, Luiz Shiguero Matsubara, Caio Henrique Paganini Burini, Priscila Lucelia Moreira, Carlos Roberto Padovani, Maria Carolina Munhoz Oliveira Nascimento, Elenize Jamas Pereira, Camila Renata Corrêa |
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| Rok vydání: | 2011 |
| Předmět: |
Male
Pathology medicine.medical_specialty Health Toxicology and Mutagenesis alpha-Tocopherol Pharmacology Toxicology Biochemistry chemistry.chemical_compound Text mining Internal medicine Weight Loss Genetics medicine Animals Rats Wistar Molecular Biology Heart health Cardiotoxicity business.industry Chemistry Myocardium food and beverages Histology Heart General Medicine Echocardiography Doppler Rats Cardiology business Biotechnology |
| Zdroj: | Humanexperimental toxicology. 30(10) |
| ISSN: | 1477-0903 |
| Popis: | The effect of pharmacological dose of α-tocopherol on heart health was determined in Wistar rats. Animals were randomly assigned to either C (control, n = 11) or E (α-tocopherol, n = 11) group. Animals received corn oil (C) or α-tocopherol dissolved in corn oil (250 mg α-tocopherol/[kg body wt/day]) (E) by gavage for a 7-week period. Rats underwent echocardiogram and were analyzed for cardiomyocyte histology and cardiac α-tocopherol absorption at the end of the study period. As compared to the C group, α-tocopherol-supplemented group showed significantly ( p < 0.05) lower body weight (E, 412.8 g vs C, 480.3 g) and total cardiac weight (E, 0.94 g vs C, 1.08 g); cardiomyocyte histological impairment; smaller left ventricle (LV) (LV end-diastolic diameter (E, 7.22 mm vs C, 7.37 mm), lower LV systolic [left ventricle fractional shortening (E, 47.6% vs C, 53.6%) and ejection fraction ratio (E, 85.4 vs C, 89.9)] and diastolic [early peak velocities of diastolic transmitral flow (E, 64.6 cm/sec vs C, 75.1 cm/sec)] function. The α-tocopherol uptake in target tissue was confirmed by determination of α-tocopherol concentration medians in cardiac tissue (E, 109.91 nmol/kg vs C, 52.09 nmol/kg). The current study indicates that pharmacological dose of α-tocopherol supplementation can induce cardiotoxicity in healthy rats. |
| Databáze: | OpenAIRE |
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