Extinction retention and the menstrual cycle: Different associations for women with posttraumatic stress disorder
| Autor: | Ann M. Rasmusson, Matthew W. King, Suzanne L. Pineles, Megan R. Gerber, Scott P. Orr, Sheeva Mostoufi, Margaret R. Bauer, Yael I. Nillni, Patricia A. Resick, Richard L. Hauger, Samantha C. Patton |
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| Rok vydání: | 2016 |
| Předmět: |
Adult
medicine.drug_class media_common.quotation_subject Physiology Extinction Psychological Stress Disorders Post-Traumatic Young Adult 03 medical and health sciences 0302 clinical medicine Conditioning Psychological medicine Humans Fear conditioning Young adult Menstrual Cycle Biological Psychiatry Menstrual cycle media_common Fear Extinction (psychology) 030227 psychiatry Clinical Psychology Psychiatry and Mental health Posttraumatic stress Estrogen Sex steroid Female Skin conductance Psychology 030217 neurology & neurosurgery |
| Zdroj: | Journal of Abnormal Psychology. 125:349-355 |
| ISSN: | 1939-1846 0021-843X |
| DOI: | 10.1037/abn0000138 |
| Popis: | The propensity to acquire and retain conditioned fear responses may contribute to the risk of developing and maintaining posttraumatic stress disorder (PTSD) following a traumatic event. There is growing evidence that the gonadal hormones estrogen and progesterone are associated with how well women retain extinction of previously conditioned fear responses. Thus, sex steroid effects may contribute to the increased prevalence of PTSD in women. For the current study, 32 nonmedicated female trauma survivors with and without PTSD completed a differential fear conditioning task both during the early follicular phase of the menstrual cycle when estradiol and progesterone levels are low, and during the midluteal phase when estradiol and progesterone levels are high. Skin conductance served as the measure of conditioned fear. Women with PTSD, compared to those without, showed impaired retention of extinction learning in the midluteal phase of the menstrual cycle. Therefore, the impact of menstrual phase on extinction retention may differ between women with and without PTSD. These findings raise potential considerations regarding the coordination of psychopharmacologic and trauma exposure-based treatments for PTSD with specific phases of the menstrual cycle. |
| Databáze: | OpenAIRE |
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