A series of immune responses leading to the induction ofT cell IL-12/IL-18 responsiveness in patientswith relatively large tumor burdens
| Autor: | Hiromi Fujiwara, Norihiko Hirai, Mari Tanigawa, Youichi Mizutani, Kazuko Uno, Hideo Saotome, Kiyotaka Okuno, Yoko Mitsuishi, Tsunataro Kishida |
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| Rok vydání: | 2003 |
| Předmět: |
Adult
CD4-Positive T-Lymphocytes Male Cancer Research T cell Immunology Population Cell Receptors Antigen T-Cell CD8-Positive T-Lymphocytes Biology Lymphocyte Activation Interferon-gamma Immune system Neoplasms medicine Humans Immunology and Allergy Postoperative Period Karnofsky Performance Status Neoplasm Metastasis education Aged Aged 80 and over education.field_of_study T-cell receptor Interleukin-18 Middle Aged Interleukin-12 CD56 Antigen Recombinant Proteins Gene Expression Regulation Neoplastic medicine.anatomical_structure Oncology Interleukin 12 Female Interleukin 18 CD8 |
| Zdroj: | Cancer Immunology, Immunotherapy. 52:33-40 |
| ISSN: | 1432-0851 0340-7004 |
| DOI: | 10.1007/s00262-002-0329-8 |
| Popis: | The induction of interleukin-12 (IL-12) responsiveness in T cells depends on T cell receptor (TCR) triggering, and is regarded as a parameter of recently TCR-sensitized T cells. Here, we investigated whether IL-12 responsiveness could be detected in freshly prepared T cells from tumor-bearing patients, and if so whether such patients exhibited additional immunological parameters related to IL-12 responsiveness. CD4(+) and CD8(+) T cell populations from an appreciable proportion of tumor-bearing patients exhibited high levels of IL-12 responsiveness as evaluated by IL-12-stimulated interferon-gamma (IFN-gamma) production. T cell populations with high IL-12 responsiveness were observed in the group of patients with moderate to large tumor mass or tumor metastases rather than in patients with small tumors. The frequency of such a T cell population was also lower in post-surgery tumor-free patients, showing the correlation between IL-12 responsiveness and the presence of a certain extent of tumor burden. More importantly, a higher incidence of IL-12 responsiveness was observed in tumor-bearing patients exhibiting detectable plasma IL-12 levels, and correlated with IL-18 responsiveness. T cell IL-12 and IL-18 responsiveness is induced by TCR triggering and subsequent IL-12 stimulation respectively. Furthermore, TCR-triggered T cells stimulate antigen-presenting cells (APC) to produce IL-12. Therefore, the present observations suggest that an immune response loop from TCR sensitization to the induction of IL-12/IL-18 responsiveness via IL-12 production operates in tumor-bearing patients, particularly in those with relatively large tumor burdens. |
| Databáze: | OpenAIRE |
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