A case of complete clearance of chronic subdural hematoma accompanied by recurrent glioblastoma multiforme after administration of bevacizumab
| Autor: | Masakazu Ogiwara, Hiroki Sato, Hiroyuki Kinouchi, Kazuya Kanemaru, Keiko Suzuki, Tomoyuki Kawataki, Kentaro Mitsuka |
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| Rok vydání: | 2014 |
| Předmět: |
Adult
Male Vascular Endothelial Growth Factor A medicine.medical_specialty Pathology genetic structures Bevacizumab Vascular permeability Pathogenesis Neovascularization 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Adjuvant therapy Medicine Humans 030212 general & internal medicine Neovascularization Pathologic business.industry General Medicine Surgery Vascular endothelial growth factor Vascular endothelial growth factor A Treatment Outcome chemistry Hematoma Subdural Chronic Neurology (clinical) Neurosurgery medicine.symptom Neoplasm Recurrence Local business Glioblastoma 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Neurosurgical review. 39(3) |
| ISSN: | 1437-2320 |
| Popis: | The efficacy of bevacizumab, a humanized monoclonal antibody against vascular endothelial growth factor (VEGF), as an adjuvant therapy against various malignant tumors was recently established. Its pharmacological effects in malignant tumors, including gliomas, were speculated to involve neovascularization inhibition and vascular permeability. Recently, it has been reported that the outer membrane of chronic subdural hematoma (CSDH) contains high levels of VEGF, which were implicated in neovascularization of the outer membrane. Furthermore, studies suggested that VEGF has the etiology in CSDH development, although its involvement is not fully understood. Here, we report the first case of chronic subdural hematoma that was improved by bevacizumab administration for recurrent glioblastoma. The present case could contribute to the hypothesis that VEGF may be associated with CSDH. We also discuss the pathogenesis and mechanism of CSDH recurrence from the viewpoint of VEGF function. |
| Databáze: | OpenAIRE |
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