Clorhexidine as a factor that promotes peritoneal adhesions in rats with induced peritonitis
| Autor: | Fabíola Alves dos Reis, Daniel Gomes de Alvarenga, Fernando Fernandes, Claudio Alvarenga Campos Mayrink, Paulo Roberto Rodrigues Bicalho, Tarcizo Afonso Nunes, Ivana Duval Araújo |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
Male
medicine.medical_specialty RD1-811 Colon medicine.medical_treatment Peritonitis Tissue Adhesions Anastomosis Severity of Illness Index Gastroenterology Peritoneal adhesions Group A Group B Postoperative Complications Reference Values Internal medicine medicine Animals Rats Wistar Ligation Saline business.industry Anastomosis Surgical Chlorhexidine Abdominal Abscess medicine.disease Surgery Rats Disease Models Animal Models Animal Anti-Infective Agents Local business medicine.drug |
| Zdroj: | Acta Cirurgica Brasileira, Volume: 28, Issue: 9, Pages: 641-645, Published: SEP 2013 Acta Cirúrgica Brasileira v.28 n.9 2013 Acta Cirúrgica Brasileira Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC) instacron:SBDPC Acta Cirurgica Brasileira, Vol 28, Iss 9, Pp 641-645 (2013) |
| Popis: | PURPOSE: To investigate the effects of chlorhexidine on the formation of adhesions and dilation of the colon at the oral end of anastomosis in the presence of peritonitis. METHODS: Peritonitis was induced in male Wistar rats by cecal ligation and puncture (CLP). Abdominal cavities were irrigated with tepid solutions containing 0.9% saline (SAL group; n=8) or 0.05% chlorhexidine (CHD group; n=8), after which colon anastomoses were performed. Control rats (n=8) were submitted to colon anastomoses but not to CLP. Animals were euthanised seven days after surgery and the incidence of adhesions, the degree of dilation of colon loops and an index were calculated to determine variables correlation. RESULTS: No animals exhibited macroscopic signs of residual peritonitis or abdominal abscesses. Adhesions were observed in 75% of control and 100% of SAL and CHD animals. Dilation of intestinal loops at the oral end of anastomosis was observed in control (50%), SAL (57.2%) and CHD (66.7%) animals. The calculated index was 1.25 in group A; 1.86 in group B; and 2.0 group C. CONCLUSION: Chlorhexidine promoted stronger adhesions and a greater dilatation of colonic loops than control group. |
| Databáze: | OpenAIRE |
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