Development of NiFe2O4/Au nanoparticles covered with lipid bilayers for applications in combined cancer therapy
| Autor: | Ana Rita Oliveira Rodrigues, Paulo J. G. Coutinho, Elisabete M. S. Castanheira, Irina S. R. Rio |
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| Přispěvatelé: | Universidade do Minho |
| Rok vydání: | 2019 |
| Předmět: |
Materials science
Nanoparticle Nanotechnology 02 engineering and technology 010402 general chemistry 01 natural sciences chemistry.chemical_compound Rhodamine B Plasmonic nanoparticles Liposome Science & Technology photothermia equipment and supplies 021001 nanoscience & nanotechnology 3. Good health 0104 chemical sciences chemistry Magnetic core magnetoliposomes Engenharia e Tecnologia::Nanotecnologia Colloidal gold Liposomes Magnetic nanoparticles drug delivery Drug delivery magnetic/plasmonic nanoparticles cancer therapy thermal therapy 0210 nano-technology human activities |
| Zdroj: | Fourth International Conference on Applications of Optics and Photonics. |
| DOI: | 10.1117/12.2527417 |
| Popis: | The potential of nanosystems with combined magnetic and plasmonic properties for biomedical applications has been recognized. Magnetic nanoparticles can enable magnetic drug targeting and hyperthermia, while plasmonic gold nanoparticles ensure effective local heating (photothermia) using relatively low energies for gold excitation. Considering cancer therapy, the combination of magnetic and plasmonic capabilities in a single multifunctional nanosystem allows magnetic guidance and production of local heat, the latter promoting triggered drug release and synergistic cytotoxic effect in cancer cells (combined chemo/phototherapy). In order to develop applications in combined cancer therapy, magnetic/plasmonic nanoparticles were prepared and covered with a lipid bilayer, these systems being able to transport drugs. The photothermia capabilities of these nanosystems were evaluated. FCT, FEDER, PORTUGAL2020 and COMPETE2020 are acknowledged for funding under Project PTDC/QUI-QFI/28020/2017 (POCI-01-0145-FEDER-028020) and Strategic Funding of CF-UM-UP (UID/FIS/04650/2013 and UID/FIS/04650/2019). |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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