Gonococcal resistance: evolving from penicillin, tetracycline to the quinolones in South Africa – implications for treatment guidelines
| Autor: | Anwar A. Hoosen, Yusuf Dangor, Mari De Jongh, Anvir Adam |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
Male
Sexually transmitted disease Spectinomycin Penicillin Resistance Microbial Sensitivity Tests Dermatology Drug resistance Quinolones beta-Lactams medicine.disease_cause Agar dilution Microbiology Gonorrhea South Africa Antibiotic resistance Drug Resistance Bacterial medicine Humans Pharmacology (medical) Urethritis Etest business.industry Tetracycline Resistance Public Health Environmental and Occupational Health Tetracycline medicine.disease Neisseria gonorrhoeae Anti-Bacterial Agents Cephalosporins Penicillin Infectious Diseases business medicine.drug |
| Zdroj: | International Journal of STD & AIDS. 18:697-699 |
| ISSN: | 1758-1052 0956-4624 |
| DOI: | 10.1258/095646207782193768 |
| Popis: | Resistant Neisseria gonorrhoeae has been evolving. This study assessed the antimicrobial susceptibility profile of isolates in the Pretoria region, South Africa. Isolates of N. gonorrhoeae from men with urethritis were tested for susceptibility to eight antimicrobial agents by disc diffusion, Etest and agar dilution methods. Chromosomal resistance to penicillin was found in 16% of isolates, 16% showed plasmid-mediated resistance and decreased susceptibility was seen in 73% of isolates. For the first time, there is evidence of high-level tetracycline resistance (36%). Ciprofloxacin resistance emerged at 7%. All isolates remained susceptible to ceftriaxone. In view of these findings of the emergence of quinolone-resistant N. gonorrhoeae, national treatment guidelines for syndromic management of sexually transmitted infections need to be urgently reviewed. The injectable preparation, ceftriaxone has to be considered as a first-line agent for the management of gonococcal infections. Overall, the gonococcal isolates in the Pretoria region remain susceptible to ceftriaxone, cefoxitin, cefpodoxime and spectinomycin. |
| Databáze: | OpenAIRE |
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