Aberrations of Cyclic Nucleotide Metabolism in the Hearts and Vessels of Hypertensive Rats
| Autor: | Gomoll Aw, Ferguson Hc, McKinney Gr, Amer Ms, Perhach Jl |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 1974 |
| Předmět: |
medicine.medical_specialty
GTP' Stimulation Aorta Thoracic Biology Adenylyl cyclase Norepinephrine (medication) chemistry.chemical_compound Stress Physiological Internal medicine medicine.artery medicine Cyclic AMP Thoracic aorta Animals Desoxycorticosterone Mesenteric arteries Biological Sciences: Cell Biology Cyclic GMP Multidisciplinary Phosphoric Diester Hydrolases Myocardium Isoproterenol Phosphodiesterase Mesenteric Arteries Rats Endocrinology medicine.anatomical_structure chemistry Guanylate Cyclase Hypertension Nucleotides Cyclic Intracellular medicine.drug Adenylyl Cyclases |
| Popis: | In the aortas and mesenteric arteries from spontaneous hypertensive rats and in the aortas from stress- and desoxycorticosterone-acetate-hypertensive rats, the intracellular cGMP: cAMP ratios were significantly elevated when compared to the ratios in the aortas of the respective controls. Decreases in the intracellular cAMP or cGMP levels were consistently associated with increased activity of the cyclic-nucleotide-specific low K m phosphodiesterase (3′:5′-cAMP 5′ nucleotidohydrolase, EC 3.1.4.17). Increases in intracellular cGMP levels were associated with elevated guanylyl cyclase [GTP pyrophosphate-lyase (cyclizing), EC 4.6.1.2] activity. Furthermore, adenylyl cyclase [ATP pyrophosphate-lyase (cyclizing), EC 4.6.1.1] activity was less sensitive to stimulation by the β-adrenergic stimulant isoproterenol in both the aortas and the hearts of the hypertensive animals. These changes could provide the biochemical basis for the ( a ) increased vascular smooth muscle tone and peripheral resistance observed in these animals, ( b ) increased reactivity to norepinephrine, and ( c ) decreased ability of aortas from hypertensive rats to relax. The presence of these same effects in different etiologic types of hypertension indicates that this aberration in cyclic nucleotide metabolism may represent a common metabolic defect basic to the hypertensive syndrome irrespective of etiology. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|