Major Adverse Noncardiac Events after PCI as Predictors of Long-Term Mortality
| Autor: | Manivel Eswaran, Subasit Acharji, Srinivas Devarakonda, Amol Raizada, R N Pamela Orshaw, F.A.C.C. Kishore J. Harjai M.D., Chetan Shenoy, Sudhakar Sattur |
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| Rok vydání: | 2008 |
| Předmět: |
Male
medicine.medical_specialty medicine.medical_treatment Contrast Media Coronary Angiography Internal medicine Myocardial Revascularization medicine Humans Radiology Nuclear Medicine and imaging Vascular Diseases cardiovascular diseases Myocardial infarction Stroke Aged Proportional Hazards Models Aged 80 and over Ejection fraction business.industry Incidence Hazard ratio Percutaneous coronary intervention Middle Aged Pennsylvania Prognosis medicine.disease Surgery Outcome and Process Assessment Health Care Treatment Outcome Conventional PCI Cardiology Female Cardiology and Cardiovascular Medicine business Mace TIMI Follow-Up Studies |
| Zdroj: | Journal of Interventional Cardiology. 21:395-402 |
| ISSN: | 1540-8183 0896-4327 |
| DOI: | 10.1111/j.1540-8183.2008.00387.x |
| Popis: | Background: Studies of percutaneous coronary intervention (PCI) routinely report major adverse cardiovascular events(MACE),butnotmajoradversenoncardiacevents(MANE)afterPCI.MANE,suchaspost-PCIbleedingand contrastnephropathy,adverselyinfluencesurvival,butarenotrecognizedasastandardcompositeofcomplications. We assessed the feasibility and prognostic utility of deriving a composite of MANE. Methods: In 985 consecutive patients who underwent PCI, we estimated the incidence and prognostic impact of in-hospital MACE (myocardial infarction [MI] target vessel revascularization, or stroke) and MANE (defined as thrombolysis in myocardial infarction [TIMI], bleeding [major or minor], or contrast nephropathy) and their impact on long-term survival. Results: The incidence of MANE was >6-fold greater than MACE (9.5% vs 1.5%). Independent correlates of MANE included age, female gender, peripheral vascular disease, lower left ventricular ejection fraction, and use of an intraaortic balloon pump (IABP) during PCI. Of 973 patients who survived the index hospitalization, death occurred in 169 (17%) at a median follow-up of 4.0 years. MANE (but not MACE) showed a significant relation with survival; 34 of 85 patients with MANE compared to 135 of 888 patients without MANE died during follow-up (40% vs 15%, log-rank P < 0.0001). After adjustment for several baseline clinical features, the occurrence of MANE was independently associated with a significant increase in long-term mortality (adjusted hazards ratio [HR] = 1.72, CI = 1.05‐2.83) and myocardial infarction (adjusted HR = 3.43, CI = 1.55‐7.58). Conclusions: After PCI, MANE are common and carry grave long-term prognostic significance. Our findings emphasize the need to monitor and report MANE, in addition to MACE, in PCI-related trials. (J Interven Cardiol 2008;21:395–402) |
| Databáze: | OpenAIRE |
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