Neurologic and hematologic response to fludarabine treatment in IgM MGUS polyneuropathy
| Autor: | M. Eurelings, J.H.J. Wokke, R. Fijnheer, H M Lokhorst, Nicolette C. Notermans, J.M.F. Niermeijer, H. Franssen |
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| Přispěvatelé: | Paediatric Neurology |
| Jazyk: | angličtina |
| Rok vydání: | 2006 |
| Předmět: |
Male
medicine.medical_specialty Paraproteinemias Gastroenterology Nerve conduction velocity Polyneuropathies Modified Rankin Scale Internal medicine Gammopathy medicine Humans Prospective Studies Aged Aged 80 and over business.industry Middle Aged medicine.disease Hematologic Response Fludarabine medicine.anatomical_structure Immunoglobulin M Immunology Female Neurology (clinical) Bone marrow business Polyneuropathy Vidarabine Monoclonal gammopathy of undetermined significance Follow-Up Studies medicine.drug |
| Zdroj: | Neurology, 67(11), 2076-2079. Lippincott Williams and Wilkins |
| ISSN: | 0028-3878 |
| Popis: | We studied the efficacy of fludarabine in 16 patients with immunoglobulin M monoclonal gammopathy of unknown significance polyneuropathy in a prospective uncontrolled trial. The modified Rankin scale improved in 5/16 patients, all of whom had a demyelinating polyneuropathy. The motor conduction velocity improved by more than 10% in two or more nerves for four of five of these patients. Hematologic response in bone marrow occurred in three of five of these patients, whereas two of five already had small polyclonal B cell populations. There were no serious side effects. |
| Databáze: | OpenAIRE |
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