Milk-soluble formula increases food intake and reduces Il6 expression in elderly rat hypothalami
| Autor: | Hassina Ould Hamouda, Delphine Crépin, Yacir Benomar, Pascale Leruyet, Bernadette Delplanque, Mohammed Taouis, Laure Riffault, Cécile Bonhomme |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Male
Aging Endocrinology Diabetes and Metabolism medicine.medical_treatment Gene Expression Adipose tissue Weight Gain Energy homeostasis Eating chemistry.chemical_compound 0302 clinical medicine Endocrinology Casein Vitamin D 2. Zero hunger 0303 health sciences Milk Proteins 3. Good health Milk Vitamin medicine.medical_specialty Hypothalamus 030209 endocrinology & metabolism Biology 03 medical and health sciences Internal medicine medicine Vitamin D and neurology Animals Humans Rats Wistar Aged 030304 developmental biology Interleukin-6 Tumor Necrosis Factor-alpha Insulin Malnutrition medicine.disease Dietary Fats Rats Disease Models Animal Insulin receptor Solubility chemistry Dietary Supplements biology.protein Insulin Resistance Energy Metabolism |
| Zdroj: | Journal of Endocrinology. 226:67-80 |
| ISSN: | 1479-6805 0022-0795 |
| Popis: | Malnutrition in the elderly is accompanied by several metabolic dysfunctions, especially alterations in energy homeostasis regulation and a loss of insulin responsiveness. Nutritional recommendations aim to enrich food with high protein and energy supplements, and protein composition and lipid quality have been widely studied. Despite the numerous studies that have examined attempts to overcome malnutrition in the elderly through such nutritional supplementation, it is still necessary to study the effects of a combination of protein, lipids, and vitamin D (VitD). This can be done in animal models of elderly malnutrition. In the present study, we investigated the effects of several diet formulae on insulin responsiveness, inflammation, and the hypothalamic expression of key genes that are involved in energy homeostasis control. To mimic elderly malnutrition in humans, elderly Wistar rats were food restricted (R, −50%) for 12 weeks and then refed for 4 weeks with one of four different isocaloric diets: a control diet; a diet where milk soluble protein (MSP) replaced casein; a blend of milk fat, rapeseed, and DHA (MRD); or a full formula (FF) diet that combined MSP and a blend of MRD (FF). All of the refeeding diets contained VitD. We concluded that: i) food restriction led to the upregulation of insulin receptor in liver and adipose tissue accompanied by increasedTnfαin the hypothalamus; ii) in all of the refed groups, refeeding led to similar body weight gain during the refeeding period; and iii) refeeding with MSP and MRD diets induced higher food intake on the fourth week of refeeding, and this increase was associated with reduced hypothalamic interleukin 6 expression. |
| Databáze: | OpenAIRE |
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