Phenylboronic acid-conjugated chitosan nanoparticles for high loading and efficient delivery of curcumin
| Autor: | Hua Yang, Jun Wang, Jing Liu, Wen-Qiao Jiao, Leyna G Liu, Dahai Liu |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Curcumin
Magnetic Resonance Spectroscopy Polymers and Plastics Cell Survival Nanoparticle Metal Nanoparticles Biocompatible Materials 02 engineering and technology Conjugated system 010402 general chemistry 01 natural sciences chemistry.chemical_compound Spheroids Cellular Materials Chemistry Humans Nanotechnology Phenylboronic acid Cell Proliferation chemistry.chemical_classification Reactive oxygen species Chitosan Drug Carriers Organic Chemistry Hep G2 Cells Hydrogen-Ion Concentration 021001 nanoscience & nanotechnology Combinatorial chemistry Boronic Acids In vitro 0104 chemical sciences Drug Liberation Kinetics chemistry Cancer cell Nanoparticles Nanocarriers 0210 nano-technology Reactive Oxygen Species |
| Zdroj: | Carbohydrate polymers. 256 |
| ISSN: | 1879-1344 |
| Popis: | In order to achieve high loading and efficient delivery of curcumin, phenylboronic acid-conjugated chitosan nanoparticles were prepared by a simple desolvation method. These nanoparticles exhibited a regular spherical shape with the average size about 200−230 nm and narrow size distribution, which were kinetically stable under physiological condition. Due to boronate ester formation between curcumin and phenylboronic acid groups in the nanoparticles, and the hydrogen bonding interactions between curcumin and nanocarriers, curcumin was successfully loaded into the nanoparticles with high drug loading content. These curcumin-loaded nanoparticles showed pH and reactive oxygen species (ROS)-triggered drug release behavior. In vitro cell experiments revealed that the blank nanoparticles were completely nontoxic to cultured cells, and the curcumin-loaded nanoparticles exhibited efficient antitumor efficiency against cancer cells. Moreover, the drug-loaded nanoparticles performed an enhanced growth inhibition in three-dimensional multicellular tumor spheroids. Thus, these nanocarriers would be a promising candidate for curcumin delivery in tumor treatment. |
| Databáze: | OpenAIRE |
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