Inhibition of tongue reflex in rats by tooth pulp stimulation during cerebral ventricle perfusion with (6–11) substance P analogs
| Autor: | Wladyslaw Z. Traczyk, Anna Janecka, Maria Zubrzycka, Wiktor Koziołkiewicz |
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| Rok vydání: | 1997 |
| Předmět: |
Male
Hypoglossal Nerve medicine.medical_specialty Drug Evaluation Preclinical Substance P Stimulation Cerebral Ventricles chemistry.chemical_compound Tongue Internal medicine Reflex medicine Animals Trigeminal Nerve Molecular Biology Dental Pulp Trigeminal nerve Chemistry General Neuroscience Electric Stimulation Rats Incisor Perfusion Endocrinology Anesthesia Cerebral ventricle Pulp (tooth) Neurology (clinical) Hypoglossal nerve Developmental Biology |
| Zdroj: | Brain Research. 753:128-132 |
| ISSN: | 0006-8993 |
| DOI: | 10.1016/s0006-8993(97)00004-8 |
| Popis: | The effect of 12 C-terminal hexapeptide analogs of substance P perfused into the cerebral ventricles on the trigemino-hypoglossal reflex caused by incisor pulp stimulation in rats was investigated. A substitution of the L-isomer by D at position 6, 7, or 8 of the substance P analogs used in this study caused the most pronounced inhibition of the trigemino-hypoglossal reflex. A correlation between the degree of inhibition of the reflex and concentration of the peptide used was observed. |
| Databáze: | OpenAIRE |
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