Rhodiasolv PolarClean – a greener alternative in solid-phase peptide synthesis
| Autor: | Anamika Sharma, Ashok Kumar, Beatriz G. de la Torre, Fernando Albericio |
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| Přispěvatelé: | Ministerio de Ciencia, Innovación y Universidades (España) |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: | |
| Zdroj: | Digital.CSIC. Repositorio Institucional del CSIC instname Green Chemistry Letters and Reviews, Vol 14, Iss 3, Pp 545-550 (2021) |
| Popis: | PolarClean, a green solvent prepared through the valorization of a byproduct of Nylon-66 manufacturing, shows an excellent capacity to dissolve all Fmoc-amino acids and key coupling reagents and additives. It can also swell polystyrene and ChemMatrix, the two resins most widely used in solid-phase peptide synthesis. The synthesis of model peptides has been carried out, rendering the target peptide as a major component. The performance of PolarClean demonstrates its utility in the toolbox for Green Solid-Phase Peptide Synthesis. The work was funded in part by the following: the National Research Foundation (NRF) of South Africa (# 105892 and Blue Sky’s Research Programme # 120386) and the University of KwaZulu-Natal (South Africa); and the Spanish Ministry of Science, Innovation, and Universities (RTI2018-093831-B-100) and the Generalitat de Catalunya (2017 SGR 1439) (Spain). |
| Databáze: | OpenAIRE |
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