Primary invasive laryngeal mycosis in an immunocompetent patient: a case report and clinico-epidemiological update

Autor:	Arunaloke Chakrabarti, Supram Hosuru Subramanya, Niranjan Nayak, Krishna Chandra Rijal, Arnab Ghosh, Joseph Jillwin, Shivaprakash M Rudramurthy
Jazyk:	angličtina
Rok vydání:	2018
Předmět:	Male 0301 basic medicine Larynx medicine.medical_specialty Itraconazole 030106 microbiology Case Report Aspergillosis Polymerase Chain Reaction Aspergillus fumigatus lcsh:Infectious and parasitic diseases Laryngeal Diseases Immunocompromised Host Young Adult 03 medical and health sciences 0302 clinical medicine medicine Humans lcsh:RC109-216 DNA Fungal 030223 otorhinolaryngology Mycosis biology business.industry Sequence Analysis DNA biology.organism_classification medicine.disease Dermatology FFPE-PCR Infectious Diseases medicine.anatomical_structure Primary laryngeal aspergillosis Etiology Histopathology business medicine.drug
Zdroj:	BMC Infectious Diseases, Vol 18, Iss 1, Pp 1-8 (2018) BMC Infectious Diseases
ISSN:	1471-2334
DOI:	10.1186/s12879-018-3219-1
Popis:	Background Laryngeal aspergillosis is uncommon and is usually secondary to pulmonary involvement in immunocompromised patients. Primary laryngeal aspergillosis in immunocompetent individuals is extremely rare, with a few cases documented over the last five decades. Case presentation We report a case of primary localised laryngeal aspergillosis in a 21-year-old apparently immunocompetent student. Septate hyphae were observed on histopathology of the laryngeal lesion, which was further confirmed as Aspergillus fumigatus after extraction of fungal DNA from formalin fixed paraffin embedded tissue (FFPET) and sequencing. The patient responded well to oral itraconazole therapy over a month. Conclusions Since last few decades, cases of primary laryngeal aspergillosis in immunocompetent individuals are on the rise, globally. This is the first case of invasive laryngeal aspergillosis reported in Nepal. The extraction of DNA from tissue and sequencing helps to identify the etiological agent, when culture fails to isolate the fungus.
Databáze:	OpenAIRE
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