Fructose and galactose enhance postexercise human liver glycogen synthesis
| Autor: | Michael Ith, Tania Buehler, Jacques Décombaz, Roy L. P. G. Jentjens, Asker E. Jeukendrup, Eva Scheurer, Chris Boesch |
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| Rok vydání: | 2011 |
| Předmět: |
Adult
Male medicine.medical_specialty Magnetic Resonance Spectroscopy 030209 endocrinology & metabolism Physical Therapy Sports Therapy and Rehabilitation Fructose Beverages 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Internal medicine Dietary Carbohydrates Humans Medicine Orthopedics and Sports Medicine Exercise physiology Glycogen synthase Exercise Human liver biology Glycogen business.industry Galactose 030229 sport sciences Maltodextrin Bicycling Liver Glycogen Endocrinology Liver metabolism Liver chemistry Exercise Test Physical Endurance biology.protein business |
| Zdroj: | Medicine and science in sports and exercise |
| DOI: | 10.1249/MSS.0b013e318218ca5a |
| Popis: | PURPOSE Both liver and muscle glycogen stores play a fundamental role in exercise and fatigue but the effect of different CHO sources on liver glycogen synthesis in humans is unclear. The aim was to compare the effect of maltodextrin (MD) drinks containing galactose fructose or glucose on postexercise liver glycogen synthesis. METHODS In this double blind triple crossover randomized clinical trial 10 well trained male cyclists performed three experimental exercise sessions separated by at least 1 wk. After performing a standard exercise protocol to exhaustion subjects ingested one of three 15 CHO solutions namely FRU (MD + fructose 2:1) GAL (MD + galactose 2:1) or GLU (MD + glucose 2:1) each providing 69 g CHO·h( 1) during 6.5 h of recovery. Liver glycogen changes were followed using (13)C magnetic resonance spectroscopy. RESULTS Liver glycogen concentration increased at faster rates with FRU (24 ± 2 mmol·L( 1)·h( 1) P < 0.001) and with GAL (28 ± 3 mmol·L( 1)·h( 1) P < 0.001) than with GLU (13 ± 2 mmol·L( 1)·h( 1)). Liver volumes increased (P < 0.001) with FRU (9 ± 2) and with GAL (10 ± 2) but not with GLU (2 ± 1 NS). Net glycogen synthesis appeared linear and was faster with FRU (8.1 ± 0.6 g·h( 1) P < 0.001) and with GAL (8.6 ± 0.9 g·h( 1) P < 0.001) than with GLU (3.7 ± 0.5 g·h( 1)). CONCLUSIONS When ingested at a rate designed to saturate intestinal CHO transport systems MD drinks with added fructose or galactose were twice as effective as MD + glucose in restoring liver glycogen during short term postexercise recovery. |
| Databáze: | OpenAIRE |
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