Reproducibility of Alzheimer's Disease Cerebrospinal Fluid-Biomarker Measurements under Clinical Routine Conditions

Autor: Jonathan Vogelgsang, Dirk Wedekind, Caroline Bouter, Hans-W. Klafki, Jens Wiltfang
Jazyk: angličtina
Rok vydání: 2018
Předmět:
0301 basic medicine
Male
Disease
cerebrospinal fluid [Amyloid beta-Peptides]
Gastroenterology
Spinal Puncture
Cohort Studies
0302 clinical medicine
Cerebrospinal fluid
Positron Emission Tomography Computed Tomography
Phosphorylation
General Neuroscience
General Medicine
amyloid beta-protein (1-42)
3. Good health
cerebrospinal fluid [Alzheimer Disease]
Psychiatry and Mental health
Clinical Psychology
cerebrospinal fluid [Biomarkers]
Biomarker (medicine)
biomarker
Female
Alzheimer’s disease
Research Article
medicine.medical_specialty
MAPT protein
human
tau Proteins
Neuropathology
amyloid-β
cerebrospinal fluid
03 medical and health sciences
Alzheimer Disease
Internal medicine
medicine
Dementia
Humans
ddc:610
cerebrospinal fluid [Peptide Fragments]
Pathological
clinical diagnostics
Aged
Reproducibility
Amyloid beta-Peptides
business.industry
Diagnostic Tests
Routine
Reproducibility of Results
amyloid beta-protein (1-40)
medicine.disease
Peptide Fragments
030104 developmental biology
cerebrospinal fluid [tau Proteins]
Geriatrics and Gerontology
Differential diagnosis
business
diagnostic imaging [Alzheimer Disease]
030217 neurology & neurosurgery
Biomarkers
Zdroj: Journal of Alzheimer's disease 62(1), 203-212 (2018). doi:10.3233/JAD-170793
Journal of Alzheimer's Disease
DOI: 10.3233/JAD-170793
Popis: Analysis of cerebrospinal fluid (CSF) is one of the key tools for the state-of-the-art differential diagnosis of dementias. Dementia due to Alzheimer’s disease (AD) is characterized by elevated CSF levels of total Tau (tTau) and phospho-181-Tau (pTau) and low CSF amyloid-β42 (Aβ42). Discrepancies in the laboratory analysis of human materials are well known and much effort has been put into harmonization procedures. In this study, we measured CSF biomarkers of more than 100 patients obtained under clinical routine conditions in two different clinical laboratories. The CSF biomarker levels obtained from the two different sites were significantly correlated: R2 = 0.7129 (tTau, p
Databáze: OpenAIRE
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