t(1;22)(p13;q13) Acute Megakaryoblastic Leukemia Complicated by Hepatic Fibrosis: Antifibrosis Therapy?
| Autor: | Margaret H.L. Ng, Alex Wing Kwan Leung, Chi Kong Li, Jianhua Feng, Frankie W.T. Cheng, Winnie C.W. Chu, Grace Kee See Lam, Natalie P. H. Chan, Terry T W Chow |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Liver Cirrhosis
congenital hereditary and neonatal diseases and abnormalities medicine.medical_specialty medicine.medical_treatment Chromosomes Human Pair 22 alpha-Tocopherol Tretinoin Gastroenterology Antioxidants Translocation Genetic Acute megakaryoblastic leukemia Keratolytic Agents Leukemia Megakaryoblastic Acute Internal medicine Antineoplastic Combined Chemotherapy Protocols medicine Effective treatment Humans Chemotherapy business.industry Liver failure Infant Newborn Treatment options Hematology medicine.disease Prognosis Leukemia Oncology Chromosomes Human Pair 1 Child Preschool Pediatrics Perinatology and Child Health Drug Therapy Combination Female Hepatic fibrosis business medicine.drug |
| Zdroj: | Journal of pediatric hematology/oncology. 43(8) |
| ISSN: | 1536-3678 |
| Popis: | Background There is no established effective treatment for patients with t(1;22)(p13;q13) acute megakaryoblastic leukemia (AMKL) and hepatic fibrosis. Observation Here we report the outcomes of 2 t(1;22)(p13;q13) AMKL patients with hepatic fibrosis. One patient died from liver failure despite the control of leukemia. The other patient was successfully treated with reduced-intensity chemotherapy and antifibrosis therapy with tretinoin and α-tocopheryl acetate, the hepatic fibrosis resolved and leukemia was in remission for 3 years. Conclusions Reduced-intensity chemotherapy plus antifibrosis therapy with tretinoin and α-tocopheryl acetate could be a treatment option for these patients with t(1;22)(p13;q13) AMKL and hepatic fibrosis. |
| Databáze: | OpenAIRE |
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