Continuously Infusing Hyperpolarized 129Xe into Flowing Aqueous Solutions Using Hydrophobic Gas Exchange Membranes
| Autor: | Bastiaan Driehuys, Harald E. Möller, Zackary I. Cleveland, Laurence W. Hedlund |
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| Rok vydání: | 2009 |
| Předmět: |
Male
Magnetic Resonance Spectroscopy Time Factors Xenon Analytical chemistry Synthetic membrane Signal Article Magnetics Materials Chemistry Animals Physical and Theoretical Chemistry Dissolution Aqueous solution Chemistry Water Membranes Artificial Microporous material Nuclear magnetic resonance spectroscopy Magnetic Resonance Imaging Rats Surfaces Coatings and Films Solutions Membrane Yield (chemistry) Hydrophobic and Hydrophilic Interactions |
| Zdroj: | The Journal of Physical Chemistry B |
| ISSN: | 1520-5207 1520-6106 |
| Popis: | Hyperpolarized (HP) (129)Xe yields high signal intensities in nuclear magnetic resonance (NMR) and, through its large chemical shift range of approximately 300 ppm, provides detailed information about the local chemical environment. To exploit these properties in aqueous solutions and living tissues requires the development of methods for efficiently dissolving HP (129)Xe over an extended time period. To this end, we have used commercially available gas exchange modules to continuously infuse concentrated HP (129)Xe into flowing liquids, including rat whole blood, for periods as long as one hour and have demonstrated the feasibility of dissolved-phase MR imaging with submillimeter resolution within minutes. These modules, which exchange gases using hydrophobic microporous polymer membranes, are compatible with a variety of liquids and are suitable for infusing HP (129)Xe into the bloodstream in vivo. Additionally, we have developed a detailed mathematical model of the infused HP (129)Xe signal dynamics that should be useful in designing improved infusion systems that yield even higher dissolved HP (129)Xe signal intensities. |
| Databáze: | OpenAIRE |
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