Use of Genetic Profiling in Leprosy to Discriminate Clinical Forms of the Disease
| Autor: | Manfred Wagner, Christoph Meinken, Euzenir Nunes Sarno, Masahiro Yamamura, Barry R. Bloom, Anne E. Burdick, Robert L. Modlin, Martin Röllinghoff, Marco Colonna, David Eisenberg, Thomas H. Rea, Steffen Stenger, Joshua R. Bleharski, Thomas G. Graeber, Maria Teresa Ochoa, Huiying Li |
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| Rok vydání: | 2003 |
| Předmět: |
Colony Count
Microbial Receptors Cell Surface Disease Biology Polymerase Chain Reaction Immune system Immunity Macrophages Alveolar Gene expression Cluster Analysis Humans Receptors Immunologic Gene Oligonucleotide Array Sequence Analysis Regulation of gene expression Immunity Cellular Principal Component Analysis Membrane Glycoproteins Multidisciplinary Genes Immunoglobulin Gene Expression Profiling Toll-Like Receptors Mycobacterium tuberculosis Leprosy Tuberculoid Immunity Innate Up-Regulation Leprosy Lepromatous Gene expression profiling Interleukin 10 Gene Expression Regulation Immunology Cytokines Algorithms |
| Zdroj: | Science. 301:1527-1530 |
| ISSN: | 1095-9203 0036-8075 |
| DOI: | 10.1126/science.1087785 |
| Popis: | Leprosy presents as a clinical and immunological spectrum of disease. With the use of gene expression profiling, we observed that a distinction in gene expression correlates with and accurately classifies the clinical form of the disease. Genes belonging to the leukocyte immunoglobulin-like receptor (LIR) family were significantly up-regulated in lesions of lepromatous patients suffering from the disseminated form of the infection. In functional studies, LIR-7 suppressed innate host defense mechanisms by shifting monocyte production from interleukin-12 toward interleukin-10 and by blocking antimicrobial activity triggered by Toll-like receptors. Gene expression profiles may be useful in defining clinical forms of disease and providing insights into the regulation of immune responses to pathogens. |
| Databáze: | OpenAIRE |
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