Unraveling framework of the ancestral Mediator complex in human diseases
| Autor: | Amelia Casamassimi, Teresa Infante, Claudio Napoli, Marcella Sessa |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Genetics
Mediator Complex Multiprotein complex Catechols RNA General Medicine Disease Biology Biochemistry MED1 Cell biology chemistry.chemical_compound Mediator Metabolic Diseases chemistry Cardiovascular Diseases Transcription (biology) RNA polymerase Transcriptional regulation Animals Humans Nervous System Diseases Inositol |
| Zdroj: | Biochimie. 94:579-587 |
| ISSN: | 0300-9084 |
| DOI: | 10.1016/j.biochi.2011.09.016 |
| Popis: | Mediator (MED) is a fundamental component of the RNA polymerase II-mediated transcription machinery. This multiprotein complex plays a pivotal role in the regulation of eukaryotic mRNA synthesis. The yeast Mediator complex consists of 26 different subunits. Recent studies indicate additional pathogenic roles for Mediator, for example during transcription elongation and non-coding RNA production. Mediator subunits have been emerging also to have pathophysiological roles suggesting MED-dependent therapeutic targets involving in several diseases, such as cancer, cardiovascular disease (CVD), metabolic and neurological disorders. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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