Gabapentin‐related Deaths: Patterns of Abuse and Postmortem Levels
| Autor: | Kathrin Hobron, Trista H. Wright, Amy M. Tharp |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Male
Drug Gabapentin Substance-Related Disorders media_common.quotation_subject GABA analogue 01 natural sciences Pathology and Forensic Medicine 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Tandem Mass Spectrometry Genetics Humans Medicine 030216 legal & forensic medicine Medical prescription Driving Under the Influence Prescription Drug Misuse Driving under the influence Retrospective Studies Cause of death media_common business.industry 010401 analytical chemistry celebrities Virginia Postmortem blood Middle Aged 0104 chemical sciences Substance Abuse Detection Vitreous Body celebrities.reason_for_arrest Suicide chemistry Accidents Postmortem Changes Anesthesia Antidepressant Female Drug Overdose Homicide business Chromatography Liquid medicine.drug |
| Zdroj: | Journal of Forensic Sciences. 64:1105-1111 |
| ISSN: | 1556-4029 0022-1198 |
| DOI: | 10.1111/1556-4029.14021 |
| Popis: | Gabapentin, a GABA analogue, is a nonopioid prescribed for seizure control and neuralgic pain. Its abuse for recreational purposes has been increasing in recent years as the number of prescriptions also increases. In our series, we review 104 cases of decedents who tested positive for gabapentin in postmortem blood samples and an additional 53 nonfatal cases of motor vehicle drivers suspected of driving under the influence. In 47.1% of the fatality cases, gabapentin was directly involved in death. Most gabapentin fatalities had several other intoxicants present (opioids, over-the-counter medications, antianxiety, and antidepressant medications). In cases in which gabapentin was determined to be a cause of death, the blood concentrations ranged from 1.1 to 134.0 mg/L. Persons who died of a gabapentin-related drug death were prescribed the drug legitimately 91.4% of the time, with 84.2% of those also having a known prior history of abuse or misuse of prescription medications. |
| Databáze: | OpenAIRE |
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