Antiepileptic Drugs (AEDs) Polypharmacy Could Lead to Buried Pharmacokinetic Interactions due to CYP450
| Autor: | Tolou-Ghamari Z |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent Clinical Biochemistry Population Pharmaceutical Science Iran Young Adult Epilepsy Cytochrome P-450 Enzyme System Pharmacokinetics Internal medicine medicine Humans Drug Interactions Pharmacology (medical) Enzyme Inhibitors Medical prescription Child education Aged Polypharmacy education.field_of_study Valproic Acid business.industry Biochemistry (medical) Potent inducer Carbamazepine Middle Aged medicine.disease Cross-Sectional Studies Enzyme Induction Anticonvulsants Drug Therapy Combination Female business medicine.drug |
| Zdroj: | Drug Metabolism Letters. 6:207-212 |
| ISSN: | 1872-3128 |
| DOI: | 10.2174/1872312811206030008 |
| Popis: | CYP450 enzymes are basics for the metabolism of several medications such as numerous AEDs. As AEDs polypharmacy could lead to hidden pharmacokinetic interactions due to CYP450, there fore, the aim of this study was to determine a proper guide line for AEDs prescription in Iranian epileptic population. A cross-sectional study of fifty-four patients' (n=23 females; n= 31 males with a mean age of 27 years) located in the Epilepsy Ward of Kashani Hospital of Isfahan University of Medical Sciences was carried out during the year 2011. Variables including sex, age, age of seizureonset, type and number of AEDs were recorded in d-Base. Results showed that the number of prescriptions based on AEDs polypharmacy was 77.8%. The most important drugs in prescriptions were carbamazepine (n=41) that is a potent inducer of CYP450 and valproic acid (n=31) that is a potent inhibitor of CYP450 simultaneously. Administration of AEDs was based on: three (n=17), four (n=7), five (n=4) or six (n=3) AEDs simultaneously. To avoid side effects, in prescribing AEDs that act as CYP450 inhibitors or inducers concomitantly, their spectrum of interactions should be predicted. |
| Databáze: | OpenAIRE |
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