Organic Nitrates and Nitrate Resistance in Diabetes: The Role of Vascular Dysfunction and Oxidative Stress with Emphasis on Antioxidant Properties of Pentaerithrityl Tetranitrate
| Autor: | Matthias Oelze, Swenja Schuhmacher, Andreas Daiber |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
lcsh:Internal medicine
Antioxidant lcsh:Specialties of internal medicine Vasodilator Agents Endocrinology Diabetes and Metabolism medicine.medical_treatment Drug Resistance Ischemia lcsh:Medicine Review Article Pharmacology Nitric Oxide medicine.disease_cause lcsh:Diseases of the endocrine glands. Clinical endocrinology Antioxidants Angina chemistry.chemical_compound Nitrate lcsh:RC581-951 Diabetes mellitus medicine Animals Humans Pentaerythritol Tetranitrate lcsh:RC31-1245 lcsh:RC648-665 Nitrates business.industry lcsh:R General Medicine medicine.disease Organic nitrates Oxidative Stress chemistry Heart failure Endothelium Vascular business Diabetic Angiopathies Oxidative stress |
| Zdroj: | Experimental Diabetes Research Experimental Diabetes Research, Vol 2010 (2010) |
| ISSN: | 1687-5303 1687-5214 |
| DOI: | 10.1155/2010/213176 |
| Popis: | Organic nitrates represent a class of drugs which are clinically used for treatment of ischemic symptoms of angina as well as for congestive heart failure based on the idea to overcome the impaired NO bioavailability by “NO” replacement therapy. The present paper is focused on parallels between diabetes mellitus and nitrate tolerance, and aims to discuss the mechanisms underlying nitrate resistance in the setting of diabetes. Since oxidative stress was identified as an important factor in the development of tolerance to organic nitrates, but also represents a hallmark of diabetic complications, this may represent a common principle for both disorders where therapeutic intervention should start. This paper examines the evidence supporting the hypothesis that pentaerithrityl tetranitrate may represent a nitrate for treatment of ischemia in diabetic patients. This evidence is based on the considerations of parallels between diabetes mellitus and nitrate tolerance as well as on preliminary data from experimental diabetes studies. |
| Databáze: | OpenAIRE |
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