Effect of minor amounts of β-calcium pyrophosphate and hydroxyapatite on the physico-chemical properties and osteoclastic resorption of β-tricalcium phosphate cylinders
| Autor: | G.A. Sblendorio, L. Niggli, Yassine Maazouz, Nicola Döbelin, Willy Hofstetter, Stefan Dolder, B. Le Gars Santoni, Marc Bohner, C. Stähli, Roman Heuberger, Paul Bowen, O. Loeffel |
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| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: |
QH301-705.5
Biomedical Engineering β‐Tricalcium phosphate 02 engineering and technology Pyrophosphate Article Hydroxyapatite Biomaterials 03 medical and health sciences chemistry.chemical_compound Osteoclast Phase (matter) medicine Osteoclastic resorption Biology (General) Materials of engineering and construction. Mechanics of materials 030304 developmental biology 0303 health sciences β tricalcium phosphate Calcium pyrophosphate Bioceramics 021001 nanoscience & nanotechnology Phosphate 3. Good health Resorption medicine.anatomical_structure β‐Calcium pyrophosphate chemistry Calcium phosphate TA401-492 0210 nano-technology Biotechnology Nuclear chemistry |
| Zdroj: | Bioactive Materials, Vol 10, Iss, Pp 222-235 (2022) Bioactive Materials |
| Popis: | β-Tricalcium Phosphate (β-TCP), one of the most used bone graft substitutes, may contain up to 5 wt% foreign phase according to standards. Typical foreign phases include β-calcium pyrophosphate (β-CPP) and hydroxyapatite (HA). Currently, the effect of small amounts of impurities on β-TCP resorption is unknown. This is surprising since pyrophosphate is a very potent osteoclast inhibitor. The main aim of this study was to assess the effect of small β-CPP fractions ( Graphical abstract Image 1 Highlights • Purest β-TCP cylinders ever reported in the literature. • Bulk Ca/P molar ratio influences the physico-chemical properties of β-TCP cylinders. • White light interferometry is a potent method to quantify osteoclastic resorption. • The presence of 1% of β-CPP reduces the in vitro β-TCP resorption rate by 40%. |
| Databáze: | OpenAIRE |
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