Two plus One: Combination Therapy Tri-systems Involving Two Membrane-Disrupting Antimicrobial Macromolecules and Antibiotics

Autor: Zeyu Shao, Erna Wulandari, Ruby C. Y. Lin, Jiangtao Xu, Kang Liang, Edgar H. H. Wong
Rok vydání: 2022
Předmět:
Zdroj: ACS Infectious Diseases. 8:1480-1490
ISSN: 2373-8227
DOI: 10.1021/acsinfecdis.2c00087
Popis: The escalating issue of multidrug-resistant (MDR) bacteria indicates the urgent need for new and effective strategies to combat this global health challenge. Here, we describe a new combinatorial approach that can be put forward for experimental therapy application against MDR bacteria. Specifically, we have developed a tri-system that includes the coadministration of two different membrane-disrupting-type antimicrobial agents─a synthetic antimicrobial polymer
Databáze: OpenAIRE