Damage induced by paracetamol compared with N -acetylcysteine
| Autor: | Mehmet Ibrahim Turan, Ebubekir Bakan, Bunyami Ozogul, Ismail Demiryilmaz, Ismayil Yilmaz, Sabri Selcuk Atamanalp, Abdullah Kisaoglu, Halis Suleyman |
|---|---|
| Přispěvatelé: | RTEÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Süleyman, Halis |
| Rok vydání: | 2014 |
| Předmět: |
Male
hepatotoxicity Antioxidant paracetamol medicine.medical_treatment Pharmacology thiamine Acetylcysteine Superoxide dismutase chemistry.chemical_compound health services administration medicine Animals rat Thiamine Aspartate Aminotransferases Rats Wistar Acetaminophen Medicine(all) chemistry.chemical_classification lcsh:R5-920 L-Lactate Dehydrogenase biology business.industry organic chemicals Glutathione peroxidase Hepatotoxicity digestive oral and skin physiology Alanine Transaminase General Medicine Glutathione Malondialdehyde Rats Paracetamol Liver chemistry Biochemistry biology.protein Rat Thiamine Pyrophosphate lcsh:Medicine (General) Thiamine pyrophosphate business medicine.drug |
| Zdroj: | Journal of the Chinese Medical Association, Vol 77, Iss 9, Pp 463-468 (2014) |
| ISSN: | 1726-4901 |
| DOI: | 10.1016/j.jcma.2014.01.011 |
| Popis: | WOS: 000342263300005 PubMed: 25028290 Background: This study investigated the effect of thiamine pyrophosphate (TPP) on oxidative liver damage induced in rats with high-dose paracetamol. Methods: Rats for this experiment were divided into the following groups: healthy control, paracetamol control, thiamine + paracetamol, TPP + paracetamol, and N-acetylcysteine + paracetamol. Oxidant and antioxidant parameters and liver function test levels were compared between the groups. Results: the results show that TPP and N-acetylcysteine with paracetamol equally prevented a rise in oxidants such as malondialdehyde and nitric oxide. They also prevented a decrease in enzymatic and nonenzymatic antioxidants such as glutathione, glutathione peroxidase, glutaredoxin, glutathione S-transferase, superoxide dismutase, and catalase in the rat liver. Conclusion: Thiamine pyrophosphate and N-acetylcysteine had a similar positive effect on oxidative damage caused by paracetamol hepatotoxicity. These findings show that TPP may be beneficial in paracetamol hepatotoxicity. Copyright (C) 2014 Elsevier Taiwan LLC and the Chinese Medical Association. All rights reserved. |
| Databáze: | OpenAIRE |
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