Increased prevalence of Parkinson's disease in soils with high arsenic levels
| Autor: | Che-Chun Su, Chien-Pang Lee, Chia-Hsin Zhu |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Adult Male Parkinson's disease Farms Office visits Taiwan chemistry.chemical_element Geographic Mapping Arsenic 03 medical and health sciences Soil 0302 clinical medicine Environmental health Arsenic Poisoning Prevalence Medicine Humans Parkinson Disease Secondary Pesticides Aged Aged 80 and over business.industry Heavy metals Parkinson Disease Middle Aged medicine.disease 030104 developmental biology Increased risk Neurology chemistry National health insurance Soil water Female Neurology (clinical) Geriatrics and Gerontology business 030217 neurology & neurosurgery |
| Zdroj: | Parkinsonismrelated disorders. 88 |
| ISSN: | 1873-5126 |
| Popis: | Introduction Exposure to arsenic (As)-containing pesticides was associated with an increased risk for Parkinson's disease (PD). Arsenic also induced in murine brains α-synuclein aggregates, a pathognomic feature of PD. Objectives People living on farms irrigated with high As water in Taiwan are likely exposed to increased As. We addressed whether increased farm soil As levels correlate with an increased PD risk. Methods We used the information from several national surveys (1983–1986) on soil metal contents to study the relationships between soil metal contents and PD prevalence in Taiwan. PD prevalence (2009–2013) was calculated with a database from Taiwan's compulsory national health insurance. A patient is defined by a PD diagnosis and prescriptions of Levodopa in three or more office visits in twelve months. We used regression models to study the correlation between PD prevalence and soil metal contents. Results The PD prevalence ranged from 83 to 213 per one hundred thousand persons in different regions of Taiwan. Among the studied heavy metals, we found only As was significantly associated with the PD prevalence. The top three regions (Yunlin, Chiayi, Tainan) in the PD prevalence list correspond exactly with the top three in soil As levels. Soil As levels and PD prevalence had a strong correlation (r = 0.75). Conclusion PD prevalence is statistically correlated with farm soil As levels in Taiwan. |
| Databáze: | OpenAIRE |
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