The Currarino triad: neurosurgical considerations
| Autor: | L.W.E. van Heurn, Gauke Kootstra, R.G.H. Beets-Tan, C.L.M. Marcelis, Emile A. M. Beuls, Pieter J. Emans, J. van Aalst, Johan S.H. Vles |
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| Přispěvatelé: | Orthopedie, Algemene Heelkunde, Klinische Genetica, Beeldvorming, Klinische Neurowetenschappen, Neurochirurgie, RS: NUTRIM School of Nutrition and Translational Research in Metabolism, RS: GROW - School for Oncology and Reproduction |
| Jazyk: | angličtina |
| Rok vydání: | 2006 |
| Předmět: |
Adult
Sacrum medicine.medical_specialty Anal Canal Meningocele Sacral Agenesis Genomic disorders and inherited multi-system disorders [IGMD 3] Central nervous system disease Humans Medicine Abnormalities Multiple Meningitis Syrinx (medicine) Spinal canal Retrospective Studies business.industry Infant Newborn Teratoma Syndrome medicine.disease Spinal cord Surgery medicine.anatomical_structure Genetic defects of metabolism [UMCN 5.1] Spinal Cord Agenesis Female Neurology (clinical) business Constipation Currarino syndrome |
| Zdroj: | Neurosurgery, 58(5), 924-929; discu. Oxford University Press Neurosurgery, 58, 924-9 Neurosurgery, 58, 5, pp. 924-9 |
| ISSN: | 0148-396X |
| Popis: | OBJECTIVES: The Currarino triad, a relatively uncommon hereditary disorder, is often associated with tethered cord and anterior myelomeningocele. Little is known of the implications of these neuroanatomic malformations or of the neurosurgical attitude. The objective of this study is to identify the spinal cord and meningeal malformations associated with the Currarino triad and to discuss the risks and benefits of surgical intervention. METHODS: We analyzed the spinal cord malformations and the neurosurgical involvement with the Currarino triad by retrospective chart review. RESULTS: The Currarino triad neuroanatomic malformations were identified in five patients. The Currarino triad was associated with a tethered cord in three patients, a myelomeningocele in five patients, a syrinx in two patients, a fistula between the colon and spinal canal in two patients, and an Arnold-Chiari Type 1 malformation in one patient. CONCLUSION: Full spine imaging is required for all patients diagnosed with the Currarino triad. Magnetic resonance imaging of the head should be performed in every patient with neuroanatomic anomalies. Surgery of an anterior myelomeningocele is not necessarily indicated, only in the rare case in which the space-occupying aspect is expected to cause constipation or problems during pregnancy or delivery. Constipation directly after birth is seen in virtually all patients with the triad. Therefore, constipation cannot be used to diagnose a tethered cord syndrome nor indicate tethered cord release. Fistulas between the spinal canal and colon have to be operated on directly. |
| Databáze: | OpenAIRE |
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