Injection molded microfluidic chips featuring integrated interconnects
Autor: | Frantisek Svec, Emil J. Geiger, Dieudonne A. Mair, Jean M. J. Fréchet, Albert P. Pisano |
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Rok vydání: | 2006 |
Předmět: |
chemistry.chemical_classification
geography Fabrication geography.geographical_feature_category Materials science Microinjections Polymers Microfluidics Biomedical Engineering Bioengineering Nanotechnology General Chemistry Polymer Microfluidic Analytical Techniques medicine.disease_cause Biochemistry chemistry Mold medicine Pressure Monolith Electroplating Porosity Ultraviolet |
Zdroj: | Lab on a chip. 6(10) |
ISSN: | 1473-0197 |
Popis: | An injection molding process for the fabrication of disposable plastic microfluidic chips with a cycle time of 2 min has been designed, developed, and implemented. Of the sixteen commercially available grades of cyclo-olefin copolymer (COC) that were screened for autofluorescence and transparency to ultraviolet (UV) light, Topas 8007 × 10 was identified as the most suitable for production. A robust solid metal mold insert defining the microfluidic channels was rapidly microfabricated using a process that significantly reduces the time required for electroplating. No wear of the insert was observed even after over 1000 cycles. The chips were bonded by thermal fusion using different bonding conditions. Each condition was tested and its suitability evaluated by burst pressure measurements. The COC microfluidic chips feature novel, integrated, reversible, standardized, ready-to-use interconnects that enable operation at pressures up to 15.6 MPa, the highest value reported to date. The suitability of these UV transparent, high pressure-resistant, disposable devices was demonstrated by in situ preparation of a high surface area porous polymer monolith within the channels. |
Databáze: | OpenAIRE |
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