Tiempo de exposición al gluten y marcadores de riesgo de diabetes mellitus insulino dependiente en pacientes celíacos
| Autor: | Gloria Ríos M, Magdalena Araya Q, Bessie Hunter M, Sandra Verbeke P, Eduardo Chávez C, Sylvia Cruchet M, Martín Gotteland R, Oscar Brunser T |
|---|---|
| Jazyk: | Spanish; Castilian |
| Rok vydání: | 2004 |
| Předmět: |
medicine.medical_specialty
Pancreatic beta cells Diabetes mellitus type I Internal medicine Diabetes mellitus medicine chemistry.chemical_classification Gluten-sensitive enteropathy Indirect immunofluorescence biology business.industry nutritional and metabolic diseases General Medicine medicine.disease Isotype Gluten digestive system diseases medicine.anatomical_structure Endocrinology chemistry Insulin dependent diabetes biology.protein Prediabetic state Gluten free Antibody Pancreas business |
| Zdroj: | Revista médica de Chile v.132 n.8 2004 SciELO Chile CONICYT Chile instacron:CONICYT |
| Popis: | Background: Celiac patients are at high risk of developing insulin-dependent diabetes mellitus, a condition that has a long pre-diabetic period. During this lapse, anti-islet cell antibodies serve as markers for future disease. This may be related with the duration of the exposure to gluten. Aim: To test the hypothesis that long term adherence to a gluten free diet decreases the frequency of risk markers for insulin dependent diabetes mellitus during adolescence and early adulthood. Patients and methods: 158 celiac patients were classified as: G1, (n=30 patients) studied at the time of diagnosis; G2 (n=97 patients) exposed to gluten as a result of non compliance with the gluten free diet and, G3 (n=31 patients) who had maintained a long term, strict gluten free diet. Isotype IgG anti-islet cell antibodies were detected by indirect immunofluorescence using monkey pancreas; results were reported in Juvenile Diabetes Foundation (JDF) units. Results: Celiac patients exposed to a gluten containing diet had a significantly higher prevalence of anti-islet cell antibodies than those who had been exposed only briefly (p |
| Databáze: | OpenAIRE |
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