Comparison of sampling methods to measure HIV RNA viral load in female genital tract secretions
| Autor: | Donald R. Hoover, Shameem Z. Jaumdally, Jo-Ann S. Passmore, Landon Myer, Heidi E. Jones, Catherine S. Todd, Nontokozo Langwenya, Jean-Mari Kriek, Hoyam Gamieldien |
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| Rok vydání: | 2017 |
| Předmět: |
Adult
0301 basic medicine Female circumcision Feminine Hygiene Products medicine.medical_specialty Adolescent Immunology Human immunodeficiency virus (HIV) HIV Infections Biology medicine.disease_cause Gastroenterology Article Specimen Handling law.invention Young Adult 03 medical and health sciences 0302 clinical medicine McNemar's test Double-Blind Method law Internal medicine medicine Humans Immunology and Allergy Sex organ 030212 general & internal medicine Endocervical swab Obstetrics and Gynecology Genitalia Female Viral Load 030112 virology Menstruation Reproductive Medicine Menstrual cup HIV-1 RNA Viral Female Viral load Intrauterine Devices |
| Zdroj: | American Journal of Reproductive Immunology. 77 |
| ISSN: | 1600-0897 1046-7408 |
| DOI: | 10.1111/aji.12619 |
| Popis: | Problem How does menstrual cup (MC) compare to other genital sampling methods for HIV RNA recovery? Method of study We compared HIV RNA levels between MC, endocervical swab (ECS), and ECS-enriched cervicovaginal lavage (eCVL) specimens in 51 HIV-positive, antiretroviral therapy-naive women at enrollment, 3 and 6 months, with order rotated by visit. Paired comparisons were analyzed with McNemar's exact tests, signed-rank tests, and an extension of Somer's D for pooled analyses across visits. Results MC specimens had the highest proportion of quantifiable HIV VL at enrollment and month 3, but more MC specimens (n=12.8%) were insufficient for testing, compared with ECS (2%, P=0.006) and eCVL (0%, P |
| Databáze: | OpenAIRE |
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