Origin, development and regulation of human Leydig cells
Autor: | Luise Landreh, Konstantin Svechnikov, J. Weisser, I. Svechnikova, G. Izzo, Olof Söder, Eugenia Colón |
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Rok vydání: | 2009 |
Předmět: |
Adult
Leptin Male endocrine system medicine.medical_specialty Sex Differentiation Endocrinology Diabetes and Metabolism Cellular differentiation Paracrine Communication Biology Paracrine signalling Endocrinology Fetus Internal medicine medicine Endocrine system Humans Insulin Involution (medicine) Hedgehog Proteins Gonadal Steroid Hormones Desert hedgehog Cell Proliferation Platelet-Derived Growth Factor Sexual differentiation Leydig Cells Proteins Cell Differentiation Ghrelin Pediatrics Perinatology and Child Health Biomarkers Hormone |
Zdroj: | Hormone research in paediatrics. 73(2) |
ISSN: | 1663-2826 |
Popis: | Sex steroids are crucial regulators of sexual differentiation and the proper development of secondary sex characteristics and patterns of sexual behavior. Since Leydig cells are the primary major producers of these steroid hormones, maintenance of the normal functions of these cells determines the reproductive capacity and fertility of males. The present minireview discusses recent findings concerning endocrine and paracrine regulation of the proliferation, differentiation and involution of human Leydig cells. The physiology and function of the two distinct fetal and adult populations of human Leydig cells are described, with particular focus on the paracrine environment that triggers their differentiation and functional maturation. The roles of established and more recently discovered paracrine regulators of this maturation, including insulin-like factor 3, platelet-derived growth factor-α, desert hedgehog, ghrelin and leptin are considered. A brief description of the origin, ontogenesis and functional markers of human fetal and adult Leydig cells is presented. |
Databáze: | OpenAIRE |
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