Real-world use of fidaxomicin in a large UK tertiary hospital: how effective is it for treating recurrent disease?
| Autor: | Reem Santos, Michael E. P. Murphy, Dunecan Massey, Sani H. Aliyu, Nicholas M. Brown, David A Enoch, Christianne Micallef, Cameron J Phillips |
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| Přispěvatelé: | Enoch, DA, Santos, R, Phillips, CJ, Micallef, C, Murphy, ME, Aliyu, SH, Massey, D, Brown, NM |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Microbiology (medical) Male medicine.medical_specialty medicine.medical_treatment 030106 microbiology Faecal transplantation Asymptomatic Tertiary Care Centers 03 medical and health sciences 0302 clinical medicine Recurrence Recurrent disease medicine Humans Fidaxomicin 030212 general & internal medicine Stage (cooking) First Recurrence Colectomy Public Environmental & Occupational Health Aged Retrospective Studies Aged 80 and over business.industry fidaxomicin recorrence General Medicine Bacterial Infections Clostridium difficile clostridium difficile Middle Aged United Kingdom Surgery Anti-Bacterial Agents Infectious Diseases Treatment Outcome Female medicine.symptom business medicine.drug |
| Zdroj: | The Journal of hospital infection. 100(2) |
| ISSN: | 1532-2939 |
| Popis: | All courses of fidaxomicin use in the study hospital were reviewed. It was used for first recurrence (six times), second recurrence (eight times) and one case of third recurrence. One patients received fidaxomicin as first-line treatment. Eight patients initially responded to therapy; of these, three patients were asymptomatic at 90 days, three patients remained asymptomatic at 30 days, and two patients had recurrences five and nine days after stopping therapy. Four patients failed to respond; of these, two patients required faecal transplantation and one patient required a colectomy. Two patients deteriorated and two patients died. Fidaxomicin was well tolerated. These findings suggest that the utility of fidaxomicin at this stage of infection is unclear. (C) 2018 The Healthcare Infection Society. Published by Elsevier Ltd. All rights reserved. Refereed/Peer-reviewed |
| Databáze: | OpenAIRE |
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