Selenium supplementation during pregnancy and lactation promotes metabolic changes in Wistar rats' offspring
| Autor: | Janaina Sena de Souza, Bruno Guimarães Marinho, Roberto Laureano-Melo, Wellington da Silva Côrtes, George Eduardo Gabriel Kluck, Guinever E. Imperio, Rodrigo Rodrigues da Conceição, Gisele Giannocco |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Male medicine.medical_specialty Physiology Offspring White adipose tissue Biology 03 medical and health sciences Selenium 0302 clinical medicine Insulin resistance Pregnancy Physiology (medical) Internal medicine Brown adipose tissue medicine Glucose homeostasis Animals Lactation Rats Wistar Pharmacology Glucose tolerance test Triiodothyronine medicine.diagnostic_test medicine.disease Rats 030104 developmental biology medicine.anatomical_structure Endocrinology Metabolism 030220 oncology & carcinogenesis Dietary Supplements Female Thyroid function |
| Zdroj: | Clinical and experimental pharmacologyphysiologyREFERENCES. 47(7) |
| ISSN: | 1440-1681 |
| Popis: | Epidemiological and animal studies have demonstrated a strong association between selenium (Se) supplementation and metabolic disorders, we aimed to evaluate whether maternal Se supplementation was able to change metabolic parameters in rats' offspring. Moreover, as Se is a deiodinase (DIO) cofactor, we decided to investigate how thyroid hormones (THs) would be involved in such metabolic changes. Thereby, two groups (n = 6, ~250 g) of female Wistar rats underwent isotonic saline or sodium selenite (1 mg/kg, p.o.) treatments. Although there were no significant differences in body weight between groups, the Se treatment during pregnancy and lactation increased milk intake and the visceral white adipose tissue (WAT) in offspring. The rats whose mothers were treated with Se also presented an improvement in the glucose tolerance test and in the glucose-stimulated insulin secretion. Regarding the lipid metabolism, the Se group had a reduction of triglycerides in the liver and in WAT. These metabolic changes were accompanied by an increase in serum triiodothyronine (T3 ) and in DIO 2 expression in brown adipose tissue (BAT). We further demonstrate an increased expression of peroxisome proliferator-activated receptor-gamma coactivator 1-alpha (PGC-1α) and nuclear respiratory factor-1 (NRF-1) mRNA in the liver. In adulthood offspring, Se supplementation programs thyroid function, glucose homeostasis, and feeding behaviour. Taken together, there is no indication that Se programming causes insulin resistance. Moreover, we conjecture that these metabolic responses are induced by increased thyroxine (T4 ) to T3 conversion by DIO2 in BAT and mediated by altered transcription factors expression associated with oxidative metabolism control in the liver. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text