Fetal thrombocytopenia in pregnancies complicated by fetal anemia due to red-cell alloimmunization: cohort study and meta-analysis
| Autor: | Laura E. Simon, Alison G. Cahill, Shayna N. Conner, Ann M. Bruno, Joshua I. Rosenbloom, George A. Macones, Methodius G. Tuuli |
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| Rok vydání: | 2019 |
| Předmět: |
medicine.medical_specialty
Gestational Age Umbilical cord Article Fetoscopy 03 medical and health sciences 0302 clinical medicine Pregnancy hemic and lymphatic diseases 030225 pediatrics medicine Humans Antigens Human Platelet 030212 general & internal medicine Retrospective Studies medicine.diagnostic_test Platelet Count Obstetrics business.industry Pregnancy Complications Hematologic Obstetrics and Gynecology Gestational age Anemia Retrospective cohort study Fetal Blood medicine.disease Thrombocytopenia Confidence interval 3. Good health Fetal Diseases medicine.anatomical_structure Blood Group Incompatibility Meta-analysis Pediatrics Perinatology and Child Health Female business Cohort study |
| Zdroj: | Journal of perinatology : official journal of the California Perinatal Association |
| ISSN: | 1476-5543 0743-8346 |
| Popis: | Objective: To estimate the prevalence and characteristics of fetal thrombocytopenia at the time of percutaneous umbilical cord sampling (PUBS) in pregnancies complicated by alloimmunization and to conduct a systematic review on fetal thrombocytopenia in these pregnancies. Study Design: Retrospective cohort study of all patients undergoing PUBS at our institution from 2000–2017. Clinical data including fetal platelet counts were abstracted from the medical record and analyzed with routine statistical procedures. A systematic review and metaanalysis were also conducted according to standard procedures. Result: At first procedure, prior to any transfusion, 13/36 fetuses (36%) had thrombocytopenia: 11/36 (31%) had moderate thrombocytopenia, and 2/36 (6%) had severe thrombocytopenia (14 patients had no platelet count at first procedure). The systematic review identified six studies, and the prevalence of fetal thrombocytopenia at the time of PUBS for alloimmunization was 18% (95% confidence interval 11%, 26%). Conclusion: Thrombocytopenia is common and underappreciated in fetuses undergoing PUBS for alloimmunization. |
| Databáze: | OpenAIRE |
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