Sexual dimorphism in the assessment of mineral apposition rate during osteoporosis
| Autor: | Pedro Henrique Silva Gomes Ferreira, Igor de Oliveira Puttini, Roberta Okamoto, Juliana Zorzi Coléte, Fábio Roberto de Souza Batista, Gustavo Antonio Correa Momesso, Frigério Pb |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Gynecology
Physics medicine.medical_specialty 030209 endocrinology & metabolism 030206 dentistry 03 medical and health sciences 0302 clinical medicine Caracteres sexuales Microscopia Microscopy medicine Sex characteristics General Earth and Planetary Sciences Osteoporosis Caracteres sexuais Osteoporose General Environmental Science |
| Zdroj: | Research, Society and Development; Vol. 10 No. 2; e4910212200 Research, Society and Development; Vol. 10 Núm. 2; e4910212200 Research, Society and Development; v. 10 n. 2; e4910212200 Research, Society and Development Universidade Federal de Itajubá (UNIFEI) instacron:UNIFEI |
| ISSN: | 2525-3409 |
| Popis: | The objective of this study was to evaluate the daily maxillary and tibial bone mineral apposition rate of ovariectomized rats and orchiectomized rats through confocal laser microscopy. Twenty-four animals were divided into 4 groups (SHAMF, OVX, SHAMM and ORQ). Six rats were distributed to the SHAMF group (submitted to fictitious surgery); six rats to the OVX group (submitted to bilateral ovariectomy); six rats to the SHAMM group (submitted to fictitious surgery) and six rats to the ORQ group (submitted to bilateral orchiectomy). On the 60th day after the surgical procedures the animals received 20 mg/kg of calcein and after 24 days 20 mg/kg of alizarin red was administered. The euthanasia was performed 18 days after the last fluorochrome administration. The histological slides obtained were submitted to confocal microscopy analysis and then dynamic histomorphometry was performed to obtain the daily mineral apposition rate (MAR). In the tibias, the values of MAR were higher for the SHAMF group (P |
| Databáze: | OpenAIRE |
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