Photobiomodulation of lymphatic drainage and clearance: perspective strategy for augmentation of meningeal lymphatic functions
| Autor: | Jürgen Kurths, Andrey Terskov, Anastassia Shnitenkova, Valeria Vinnik, Alexander Dubrovsky, Maria Klimova, Nikita Lezhnev, Ilana Agranovich, Inna Blokhina, Oxana Semyachkina-Glushkovskaya, Arkady S. Abdurashitov, Alexander Shirokov, Anna Kuzmina, Valery V. Tuchin, Edik U. Rafailov |
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| Rok vydání: | 2019 |
| Předmět: |
Pathology
medicine.medical_specialty Meningeal lymphatic vessels Lymphatic functions government.form_of_government Vasodilation Stimulation 01 natural sciences Article 010309 optics 03 medical and health sciences Confocal imaging Disease control 0103 physical sciences medicine 030304 developmental biology 0303 health sciences business.industry fungi Atomic and Molecular Physics and Optics Lymphatic Endothelium Lymphatic system Clearing functions government Nanorods business Biotechnology |
| Zdroj: | Biomedical optics express. 11(2) |
| ISSN: | 2156-7085 |
| Popis: | There is a hypothesis that augmentation of the drainage and clearing function of the meningeal lymphatic vessels (MLVs) might be a promising therapeutic target for preventing neurological diseases. Here we investigate mechanisms of photobiomodulation (PBM, 1267 nm) of lymphatic drainage and clearance. Our results obtained at optical coherence tomography (OCT) give strong evidence that low PBM doses (5 and 10 J/cm2) stimulate drainage function of the lymphatic vessels via vasodilation (OCT data on the mesenteric lymphatics) and stimulation of lymphatic clearance (OCT data on clearance of gold nanorods from the brain) that was supported by confocal imaging of clearance of FITC-dextran from the cortex via MLVs. We assume that PBM-mediated relaxation of the lymphatic vessels can be possible mechanisms underlying increasing the permeability of the lymphatic endothelium that allows molecules transported by the lymphatic vessels and explain PBM stimulation of lymphatic drainage and clearance. These findings open new strategies for the stimulation of MLVs functions and non-pharmacological therapy of brain diseases. |
| Databáze: | OpenAIRE |
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